Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues.
Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues.
复制标题
肥大细胞通过修复通过感染组织的树突状细胞运输来增强自适应免疫。
DOI：
10.1016/j.chom.2009.09.004
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发表时间：
2009-10-22
影响因子：
30.3
通讯作者：
Abraham SN
中科院分区：
文献类型：
--
作者：
Shelburne CP;Nakano H;St John AL;Chan C;McLachlan JB;Gunn MD;Staats HF;Abraham SN
肥大细胞（MC）最为人所知的是引起有害反应，主要是在初级免疫已经建立之后。在这里，我们报告说，在E。大肠杆菌感染后，MC缺陷小鼠的主要体液反应显著减弱，并且发现与MC充足的对应物的反应相比，在尿路感染（UTI）模型中的保护性较低。发现MC募集大量树突状细胞（DC）进入感染的组织部位，其最终在长时间过程中迁移到引流淋巴结（DLN）。这种运输模式是由MC产生的TNF促进的，TNF增加了局部血管上E-选择素的表达。E-选择素的抗体阻断抑制DC募集到感染部位和DLN中，从而损害原发性体液免疫应答。因此，在感染过程中，常驻MC通过从循环中募集DC进入感染部位，促进初级保护性适应性反应。
Mast cells (MCs) are best known for eliciting harmful reactions, mostly after primary immunity has been established. Here, we report that during E. coli infection, the primary humoral response in MC-deficient mice is significantly diminished, and was found to be less protective in a urinary tract infection (UTI) model compared to the response from MC-sufficient counterparts. MCs were found to recruit large numbers of dendritic cells (DCs) into the infected tissue site, which eventually migrated into draining lymph nodes (DLNs) over a prolonged time-course. This pattern of trafficking was facilitated by MC generated TNF, which increased the expression of E-selectin on local blood vessels. Antibody blockade of E-selectin inhibited DC recruitment into the site of infection and DLNs, and consequently impaired the primary humoral immune response. Thus, during infection, resident MCs contribute to the primary protective adaptive response through recruitment of DCs from the circulation into infected sites.
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DOI：
10.1084/jem.20030448
发表时间：
2003-08-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
MartIn-Fontecha A;Sebastiani S;Höpken UE;Uguccioni M;Lipp M;Lanzavecchia A;Sallusto F
通讯作者：
Sallusto F
影响因子：
64.8
作者：
Malaviya, R;Ikeda, T;Abraham, SN
通讯作者：
Abraham, SN
影响因子：
20.3
作者：
Heib, Valeska;Becker, Marc;Stassen, Michael
通讯作者：
Stassen, Michael
影响因子：
4.4
作者：
Suto, Hajime;Nakae, Susumu;Galli, Stephen J.
通讯作者：
Galli, Stephen J.
影响因子：
6
作者：
Siebenhaar, Frank;Syska, Wolfgang;Maurer, Marcus
通讯作者：
Maurer, Marcus