Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics.
Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics.
复制标题
DOI：
10.1038/s41598-018-29618-w
复制
发表时间：
2018-07-26
影响因子：
4.6
通讯作者：
Wiedwald U
中科院分区：
文献类型：
--
作者：
Efremova MV;Naumenko VA;Spasova M;Garanina AS;Abakumov MA;Blokhina AD;Melnikov PA;Prelovskaya AO;Heidelmann M;Li ZA;Ma Z;Shchetinin IV;Golovin YI;Kireev II;Savchenko AG;Chekhonin VP;Klyachko NL;Farle M;Majouga AG;Wiedwald U
采用改进的湿化学合成方法，在9纳米的Au种子纳米颗粒上外延生长出高质量的25纳米八面体Fe3O4磁铁矿纳米晶体。这些Fe3O4-Au Janus纳米颗粒表现出块状磁性。由于其高磁化强度和八面体形状，与其他类型的Fe3O4-Au杂化物和商用造影剂相比，这些杂化物在体外和体内的T2弛豫率都优于其他类型的Fe3O4-Au杂化物和商用造影剂。纳米颗粒为治疗应用提供了两个功能表面。首次将Fe3O4-Au杂化物与两种荧光染料或药物与染料的组合偶联，从而在体外和体内同时跟踪纳米颗粒载体和药物货物。通过活体显微镜可以实时显示药物的输送和有效载荷的释放。用细胞特异性分子和药物取代染料，使得Fe3O4-Au杂化物成为治疗学中独特的一体化平台。
High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T2 relaxivity for magnetic resonance imaging as compared to other types of Fe3O4-Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe3O4-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe3O4-Au hybrids a unique all-in-one platform for theranostics.
登录
查看更多内容
影响因子：
17.1
作者：
Efremova, Maria, V;Veselov, Maxim M.;Klyachko, Natalia L.
通讯作者：
Klyachko, Natalia L.
影响因子：
12.4
作者：
Gao N;Bozeman EN;Qian W;Wang L;Chen H;Lipowska M;Staley CA;Wang YA;Mao H;Yang L
通讯作者：
Yang L
影响因子：
10.8
作者：
Cha, Eui-Joon;Jang, Eue Soon;Ahn, Cheol-Hee
通讯作者：
Ahn, Cheol-Hee
影响因子：
6.7
作者：
Fornaguera, Cristina;Caldero, Gabriela;Vauthier, Christine
通讯作者：
Vauthier, Christine
DOI：
10.1016/j.jconrel.2015.09.038
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Golovin YI;Gribanovsky SL;Golovin DY;Klyachko NL;Majouga AG;Master АM;Sokolsky M;Kabanov AV
通讯作者：
Kabanov AV