Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus.
Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus.
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DOI：
10.1038/srep01563
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发表时间：
2013
影响因子：
4.6
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
--
作者：
Kiso, Maki;Takano, Ryo;Sakabe, Saori;Katsura, Hiroaki;Shinya, Kyoko;Uraki, Ryuta;Watanabe, Shinji;Saito, Hiroshi;Toba, Masamichi;Kohda, Noriyuki;Kawaoka, Yoshihiro
甲型流感（H1N1）pdm病毒引起了21世纪世纪的第一次人类大流行。虽然各种益生菌乳酸菌物种已被证明对肺炎诱导病原体具有抗微生物作用，但其预防功效和保护机制在很大程度上仍然未知。在这里，我们评估了热灭活戊糖乳杆菌b240对致命的甲型流感（H1N1）pdm病毒感染的预防效果在小鼠模型中。为了进一步确定b240诱导的保护性反应，我们对小鼠肺进行了病毒学、组织病理学和转录组学分析。虽然我们没有观察到b240对病毒生长、细胞因子产生或组织病理学的明显影响，但基因表达分析显示，口服b240可不同程度地调节小鼠肺中抗病毒基因的表达。我们的研究结果揭示了b240介导的抗流感病毒感染的可能机制，并为益生菌治疗提供了新的见解。
Influenza A(H1N1)pdm virus caused the first human pandemic of the 21st century. Although various probiotic Lactobacillus species have been shown to have anti-microbial effects against pneumonia-inducing pathogens, the prophylactic efficacy and mechanisms behind their protection remain largely unknown. Here, we evaluated the prophylactic efficacy of heat-killed Lactobacillus pentosus b240 against lethal influenza A(H1N1)pdm virus infection in a mouse model. To further define the protective responses induced by b240, we performed virologic, histopathologic, and transcriptomic analyses on the mouse lungs. Although we did not observe an appreciable effect of b240 on virus growth, cytokine production, or histopathology, gene expressional analysis revealed that oral administration of b240 differentially regulates antiviral gene expression in mouse lungs. Our results unveil the possible mechanisms behind the protection mediated by b240 against influenza virus infection and provide new insights into probiotic therapy.
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影响因子：
168.9
作者：
Gubareva, LV;Kaiser, L;Hayden, FG
通讯作者：
Hayden, FG
DOI：
10.1186/1742-4933-7-11
发表时间：
2010-08-26
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Kotani Y;Shinkai S;Okamatsu H;Toba M;Ogawa K;Yoshida H;Fukaya T;Fujiwara Y;Chaves PH;Kakumoto K;Kohda N
通讯作者：
Kohda N
影响因子：
1.9
作者：
Di Nunzio, Mattia;Danesi, Francesca;Bordoni, Alessandra
通讯作者：
Bordoni, Alessandra
DOI：
10.1074/jbc.m807261200
发表时间：
2009-02-13
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hinson ER;Cresswell P
通讯作者：
Cresswell P
影响因子：
3.1
作者：
Kim, Charles C.;Parikh, Sunil;DeRisi, Joseph L.
通讯作者：
DeRisi, Joseph L.