IVUS-based FSI models for human coronary plaque progression study: components, correlation and predictive analysis.
IVUS-based FSI models for human coronary plaque progression study: components, correlation and predictive analysis.
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基于 IVUS 的 FSI 模型用于人类冠状动脉斑块进展研究：成分、相关性和预测分析
DOI：
10.1007/s10439-014-1118-1
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发表时间：
2015-01
影响因子：
3.8
通讯作者：
Tang, Dalin
中科院分区：
文献类型：
--
作者：
Wang, Liang;Wu, Zheyang;Yang, Chun;Zheng, Jie;Bach, Richard;Muccigrosso, David;Billiar, Kristen;Maehara, Akiko;Mintz, Gary S.;Tang, Dalin
动脉粥样硬化斑块的进展被认为与机械应力条件有关。获取患者体内血管内超声冠状动脉斑块随访数据，构建循环弯曲的流固相互作用（FSI）模型，获得流壁剪切应力（WSS）、斑块壁应力（PWS）和应变（PWSn）数据，并研究通过壁厚增加（WTI）、帽厚增加（CTI）、脂质深度增加（LDI）测量的斑块进展与壁厚（WT）、WSS、PWS和PWSn等危险因素之间的相关性。取各切片形态学和力学因素的四分之一平均值（n= 178-1016）进行分析。介绍了一种预测方法来评估危险因素的预测准确性，并确定斑块进展的最佳预测因子。壁厚和斑块壁应力的组合被确定为WTI测量的斑块进展的最佳预测因子。斑块壁厚与WTI （r= - 0.7363, p<1e-10）、帽厚（r=0.4541, p<1e-10）、CTI （r= - 0.4217, p<1e-8）、LD （r=0.4160, p<1e-10）、LDI （r= - 0.4491, p<1e-10）的整体相关性最好，其次是斑块壁应力(与WTI (r= - 0.3208, p<1e-10)；帽厚：（r=0.4541, p<1e-10）；CTI:(r =−0.1719,p=0.0190)；LD:(r= - 0.2206, p<1e-10)；LDI: r=0.1775, p<0.0001)。墙体剪应力的相关结果不一致。
Atherosclerotic plaque progression is believed to be associated with mechanical stress conditions. Patient follow-up in vivo intravascular ultrasound coronary plaque data were acquired to construct fluid-structure interaction (FSI) models with cyclic bending to obtain flow wall shear stress (WSS), plaque wall stress (PWS) and strain (PWSn) data and investigate correlations between plaque progression measured by wall thickness increase (WTI), cap thickness increase (CTI), lipid depth increase (LDI) and risk factors including wall thickness (WT), WSS, PWS, and PWSn. Quarter average values (n=178–1016) of morphological and mechanical factors from all slices were obtained for analysis. A predictive method was introduced to assess prediction accuracy of risk factors and identify the optimal predictor(s) for plaque progression. A combination of wall thickness and plaque wall stress was identified as the best predictor for plaque progression measured by WTI. Plaque wall thickness had best overall correlation with WTI (r=−0.7363, p<1e-10), cap thickness (r=0.4541, p<1e-10), CTI (r = − 0.4217, p<1e-8), LD (r=0.4160, p<1e-10), and LDI (r= −0.4491, p<1e-10), followed by plaque wall stress (with WTI: (r = − 0.3208, p<1e-10); cap thickness: (r=0.4541, p<1e-10); CTI: (r = − 0.1719, p=0.0190); LD: (r= − 0.2206, p<1e-10); LDI: r=0.1775, p<0.0001). Wall shear stress had mixed correlation results.
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影响因子：
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作者：
Tang D;Yang C;Canton G;Wu Z;Hatsukami T;Yuan C
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DOI：
10.1152/ajpheart.00005.2008
发表时间：
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影响因子：
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作者：
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通讯作者：
Pettigrew, Roderic I.
DOI：
10.1080/00949659308811554
发表时间：
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影响因子：
1.2
作者：
WOLFINGER, R;OCONNELL, M
通讯作者：
OCONNELL, M