Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling.
Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling.
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DOI：
10.1016/j.jbiomech.2011.11.019
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发表时间：
2012-03-15
影响因子：
2.4
通讯作者：
Billiar, Kristen L.
中科院分区：
文献类型：
--
作者：
Kural, Mehmet H.;Cai, Mingchao;Tang, Dalin;Gwyther, Tracy;Zheng, Jie;Billiar, Kristen L.
计算模型有可能提供与冠状动脉斑块破裂部位相关的应力和应变的精确估计。然而，缺乏对患病人体血管壁力学特性的充分数学描述阻碍了计算的准确性。本研究的目的是利用平面双轴测试来表征患病人类冠状动脉和颈动脉的行为。与人类颈动脉标本和通常报道的猪冠状动脉值相比，患病冠状动脉标本在最大等双轴应力（250 kPa）下表现出相对较高的刚度（50-210 kPa）和较低的延伸性（1-10%）。组织学上观察到的厚的新内膜层似乎与硬度升高和标本的各向异性方向有关。Fung， Choi-Vito和修正的Mooney-Rivlin本构方程可以很好地拟合来自多种应力协议的多轴数据，并将代表性冠状动脉标本的参数用于具有流固相互作用的有限元模型中。计算出的最大应力和应变的位置发生了很大的变化，并且血管壁上的最大主应力（48-65 kPa）和应变（6.5-8%）的大小低于先前使用单轴试验参数预测的值。综上所述，结果证明了在患者特定计算模型中利用疾病匹配的多轴本构关系来准确预测病变冠状动脉内的应力和应变的重要性。
Computational models have the potential to provide precise estimates of stresses and strains associated with sites of coronary plaque rupture. However, lack of adequate mathematical description of diseased human vessel wall mechanical properties is hindering computational accuracy. The goal of this study is to characterize the behavior of diseased human coronary and carotid arteries using planar biaxial testing. Diseased coronary specimens exhibit relatively high stiffness (50–210 kPa) and low extensibility (1–10%) at maximum equibiaxial stress (250 kPa) compared to human carotid specimens and values commonly reported for porcine coronary arteries. A thick neointimal layer observed histologically appears to be associated with heightened stiffness and the direction of anisotropy of the specimens. Fung, Choi-Vito and modified Mooney-Rivlin constitutive equations fit the multiaxial data from multiple stress protocols well, and parameters from representative coronary specimens were utilized in a finite element model with fluid-solid interactions. Computed locations of maximal stress and strain are substantially altered, and magnitudes of maximum principal stress (48–65 kPa) and strain (6.5–8%) in the vessel wall are lower than previously predicted using parameters from uniaxial tests. Taken together, the results demonstrate the importance of utilizing disease-matched multiaxial constitutive relationships within patient-specific computational models to accurately predict stress and strain within diseased coronary arteries.
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影响因子：
2.4
作者：
Humphrey, J. D.;Eberth, J. F.;Dye, W. W.;Gleason, R. L.
通讯作者：
Gleason, R. L.
影响因子：
4.6
作者：
van Andel, CJ;Pistecky, PV;Borst, C
通讯作者：
Borst, C
影响因子：
3.5
作者：
van den Broek, Chantal N.;van der Horst, Arjen;van de Vosse, Frans N.
通讯作者：
van de Vosse, Frans N.
DOI：
10.1109/tbme.2009.2025658
发表时间：
2009-10
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Yang C;Bach RG;Zheng J;Naqa IE;Woodard PK;Teng Z;Billiar K;Tang D
通讯作者：
Tang D
DOI：
10.1115/1.2891166
发表时间：
1990-05-01
影响因子：
1.7
作者：
CHOI, HS;VITO, RP
通讯作者：
VITO, RP