Perfringolysin O: The Underrated Clostridium perfringens Toxin?
Perfringolysin O: The Underrated Clostridium perfringens Toxin?
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DOI：
10.3390/toxins7051702
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发表时间：
2015-05-14
期刊：
影响因子：
4.2
通讯作者：
Van Immerseel F
中科院分区：
文献类型：
--
作者：
Verherstraeten S;Goossens E;Valgaeren B;Pardon B;Timbermont L;Haesebrouck F;Ducatelle R;Deprez P;Wade KR;Tweten R;Van Immerseel F
厌氧细菌产气荚膜梭菌表达多种毒素，促进人类和动物的疾病发展。一种这样的毒素是产气荚膜溶血素O(PFO，经典地称为θ毒素)，一种形成孔的胆固醇依赖的细胞溶血素。PFO作为一种水溶性单体分泌，通过胆固醇识别和结合细胞膜。膜结合的单体经历结构变化，最终在膜表面形成寡聚化的预孔复合体。然后，将预制孔转化为直径约为250-300ä的双层跨孔。PFO在几乎所有已鉴定的产气荚膜梭菌菌株中都有表达，并具有有趣的特征，表明PFO在疾病发展中的潜在作用尚未确定。研究已经证明了PFO在气体坏疽进展和牛坏死性出血性肠炎中的作用，但现有的数据有限，无法确定PFO是否也在由产气荚膜梭菌引起的其他疾病表现中发挥作用。这篇综述总结了已知的PFO的结构和功能特征，同时强调了对PFO在疾病发病机制中的潜在贡献的最新见解。
The anaerobic bacterium Clostridium perfringens expresses multiple toxins that promote disease development in both humans and animals. One such toxin is perfringolysin O (PFO, classically referred to as θ toxin), a pore-forming cholesterol-dependent cytolysin (CDC). PFO is secreted as a water-soluble monomer that recognizes and binds membranes via cholesterol. Membrane-bound monomers undergo structural changes that culminate in the formation of an oligomerized prepore complex on the membrane surface. The prepore then undergoes conversion into the bilayer-spanning pore measuring approximately 250–300 Å in diameter. PFO is expressed in nearly all identified C. perfringens strains and harbors interesting traits that suggest a potential undefined role for PFO in disease development. Research has demonstrated a role for PFO in gas gangrene progression and bovine necrohemorrhagic enteritis, but there is limited data available to determine if PFO also functions in additional disease presentations caused by C. perfringens. This review summarizes the known structural and functional characteristics of PFO, while highlighting recent insights into the potential contributions of PFO to disease pathogenesis.
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影响因子：
3
作者：
Bryant, AE;Bayer, CR;Stevens, DL
通讯作者：
Stevens, DL
影响因子：
3.1
作者：
Bryant, AE;Stevens, DL
通讯作者：
Stevens, DL
影响因子：
3.2
作者：
BaThein, W;Lyristis, M;Shimizu, T
通讯作者：
Shimizu, T
影响因子：
6.4
作者：
ASMUTH, DM;OLSON, RD;STEVENS, DL
通讯作者：
STEVENS, DL
影响因子：
2.9
作者：
Flanagan, John J.;Tweten, Rodney K.;Heuck, Alejandro P.
通讯作者：
Heuck, Alejandro P.