Antihyperlipidemic and Antitumor Effects of Chickpea Albumin Hydrolysate
Antihyperlipidemic and Antitumor Effects of Chickpea Albumin Hydrolysate
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鹰嘴豆白蛋白水解物的降血脂和抗肿瘤作用
DOI：
10.1007/s11130-012-0311-3
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发表时间：
2012-09
影响因子：
4
通讯作者：
Xiaohong Kou(*)
中科院分区：
文献类型：
--
作者：
Zhijun Zhang;Wancong Yu.;Hua Wang.;Xiaohong Kou(*)
本研究旨在探讨鹰嘴豆蛋白水解物（CAH）的降血脂和抗肿瘤作用。抗高血压实验结果表明，CAH能剂量依赖性地降低血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C），升高高密度脂蛋白胆固醇（HDL-C）。此外，高脂血症肝脏的外观也得到了显著改善。抗肿瘤实验结果表明，CAH能显著提高抑瘤率，缩小肿瘤体积。CAH还能增加脾指数，促进脾淋巴细胞增殖。此外，CAH处理导致了一个显着的超氧化物歧化酶（SOD）的活性上升，而显着降低丙二醛（MDA）在肝脏中。最重要的是，我们发现CAH试验组小鼠的身体状况，如食欲、活动和皮毛光泽，优于肿瘤对照组（TC）和阳性对照组（PC）。这些结果共同表明，CAH值得进一步研究和开发作为一种控制肝脏脂质，以及抗肿瘤和降血脂治疗的辅助元素。
This study was undertaken to determine the effects of chickpea albumin hydrolysate (CAH) on antihyperlipidemic and antitumor functions. The antihyperlipidemic results showed that CAH exhibited a dose dependent ability to decrease the levels of serum total cholesterol, triglyceride, LDL cholesterol (LDL-C), while increasing HDL cholesterol (HDL-C). Additionally, the appearance of the hyperlipidemic livers was ameliorated significantly. The antitumor results showed that CAH administration significantly increased the tumor inhibition rate and decreased tumor volume. CAH was also able to increase the spleen index and promote spleen lymphocyte proliferation. In addition, CAH treatment led to a remarkable rise in the superoxide dismutase (SOD) activity, while dramatically decreasing malondialdehyde (MDA) in the liver. Most importantly, we found that the physical conditions, such as appetite, activity, and coat luster of the mice in the CAH test group were better than those in the tumor control (TC) and positive control (PC) groups. These results taken together indicate that CAH warrants being further investigated and developed as an adjunctive element for hepatic lipid control, as well as antitumor and hypolipidemic therapies.
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影响因子：
4
作者：
Lee, Bo-Bae;Cha, Mi-Ran;Lee, Seung-Cheol
通讯作者：
Lee, Seung-Cheol
DOI：
10.1016/j.etp.2009.06.013
发表时间：
2010-09
期刊：
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
影响因子：
--
作者：
Zhaohui Xue;Zhiwei Liu;Moucheng Wu;Shiwen Zhuang;Wancong Yu
通讯作者：
Zhaohui Xue;Zhiwei Liu;Moucheng Wu;Shiwen Zhuang;Wancong Yu
DOI：
10.1016/j.biopha.2005.03.004
发表时间：
2005-05
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
D. S. St. Clair;Yunfeng Zhao;L. Chaiswing;T. Oberley
通讯作者：
D. S. St. Clair;Yunfeng Zhao;L. Chaiswing;T. Oberley
影响因子：
4
作者：
Valcheva-Kuzmanova, S.;Kuzmanov, K.;Belcheva, A.
通讯作者：
Belcheva, A.
影响因子：
8.8
作者：
Clemente, A;Vioque, J;Millán, F
通讯作者：
Millán, F