Computational investigation of blood cell transport in retinal microaneurysms.
Computational investigation of blood cell transport in retinal microaneurysms.
复制标题
DOI：
10.1371/journal.pcbi.1009728
复制
发表时间：
2022-01
影响因子：
4.3
通讯作者：
Karniadakis GE
中科院分区：
文献类型：
--
作者：
Li H;Deng Y;Sampani K;Cai S;Li Z;Sun JK;Karniadakis GE
微动脉瘤（MA）是糖尿病视网膜病变（DR）最早的临床可见症状之一。 MA 渗漏或破裂可能会导致周围神经视网膜出现局部病变，从而影响视觉功能。 MA 中的血栓形成可能会影响其周转时间，这是与糖尿病眼的视觉和解剖结果相关的指标。在这项工作中，我们对包含各种 MA 的微通道中的血流进行计算建模，以研究 DR 中 MA 的病理学。本研究中采用的基于粒子的模型可以明确地表示红细胞（RBC）和血小板以及它们在血流中的相互作用，这是一个很难在体内观察到的过程。我们的模拟表明，虽然来自母血管的主要血流可以灌注体颈比（BNR）较小的MA的整个管腔，但它只能灌注BNR较大的MA的部分管腔，特别是在低血细胞比容水平下，导致MA内部可能出现缺氧状况。我们还量化了 MA 大小、血流速度、血细胞比容、红细胞硬度和粘附力对血小板进入 MA 的可能性及其在内部停留时间的影响，这两个因素被认为与 MA 中血栓形成相关。我们的研究结果表明，MA尺寸增大、MA母血管中血流速度和血细胞比容增加以及RBC-RBC粘附促进血小板迁移到MA中并延长其停留时间，从而增加MA内血栓形成的倾向。总的来说，我们的工作表明，使用基于粒子的模型进行计算模拟可以帮助理解与 DR 中的 MA 相关的微血管病理学，并为刺激和指导该领域的新实验和计算研究提供见解。微动脉瘤（MA）是糖尿病视网膜病变（DR）最早的临床可见症状之一。 MA 渗漏或破裂可能会导致周围神经视网膜出现局部病变，从而影响视觉功能。在这项工作中，我们对包含各种 MA 的微通道中的血流进行计算建模，以研究 DR 中 MA 的病理学。本研究中采用的基于粒子的模型可以明确地表示红细胞（RBC）和血小板以及它们在血流中的相互作用，这是一个很难在体内观察到的过程。我们的模拟表明，虽然来自载瘤血管的主要血流可以灌注小 MA 的整个管腔，但它只能灌注大 MA 的部分管腔。我们的结果还表明，MA尺寸增大、MA母血管血流速度和血细胞比容增加以及RBC-RBC粘附促进血小板迁移到MA中，从而增加MA内血栓形成的倾向。总的来说，我们的工作表明，使用基于粒子的模型进行计算模拟可以帮助理解与 DR 中的 MA 相关的微血管病理学，并为刺激和指导该领域的新实验和计算研究提供见解。
Microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy (DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina that impacts visual function. Thrombosis in MAs may affect their turnover time, an indicator associated with visual and anatomic outcomes in the diabetic eyes. In this work, we perform computational modeling of blood flow in microchannels containing various MAs to investigate the pathologies of MAs in DR. The particle-based model employed in this study can explicitly represent red blood cells (RBCs) and platelets as well as their interaction in the blood flow, a process that is very difficult to observe in vivo. Our simulations illustrate that while the main blood flow from the parent vessels can perfuse the entire lumen of MAs with small body-to-neck ratio (BNR), it can only perfuse part of the lumen in MAs with large BNR, particularly at a low hematocrit level, leading to possible hypoxic conditions inside MAs. We also quantify the impacts of the size of MAs, blood flow velocity, hematocrit and RBC stiffness and adhesion on the likelihood of platelets entering MAs as well as their residence time inside, two factors that are thought to be associated with thrombus formation in MAs. Our results show that enlarged MA size, increased blood velocity and hematocrit in the parent vessel of MAs as well as the RBC-RBC adhesion promote the migration of platelets into MAs and also prolong their residence time, thereby increasing the propensity of thrombosis within MAs. Overall, our work suggests that computational simulations using particle-based models can help to understand the microvascular pathology pertaining to MAs in DR and provide insights to stimulate and steer new experimental and computational studies in this area. Microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy (DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina that impacts visual function. In this work, we perform computational modeling of blood flow in microchannels containing various MAs to investigate the pathologies of MAs in DR. The particle-based model employed in this study can explicitly represent red blood cells (RBCs) and platelets as well as their interaction in the blood flow, a process that is very difficult to observe in vivo. Our simulations illustrate that while the main blood flow from the parent vessels can perfuse the entire lumen of small MAs, it can only perfuse part of the lumen in large MAs. Our results also show that enlarged MA size, increased blood velocity and hematocrit in the parent vessel of MAs as well as the RBC-RBC adhesion promote the migration of platelets into MAs, thereby increasing the propensity of thrombosis within MAs. Overall, our work suggests that computational simulations using particle-based models can help to understand the microvascular pathology pertaining to MAs in DR and provide insights to stimulate and steer new experimental and computational studies in this area.
登录
查看更多内容
影响因子：
4.3
作者：
Czaja, Benjamin;Gutierrez, Mario;Eniola-Adefeso, Omolola
通讯作者：
Eniola-Adefeso, Omolola
影响因子：
4.3
作者：
Chang HY;Li X;Li H;Karniadakis GE
通讯作者：
Karniadakis GE
影响因子：
3.6
作者：
de Castro, Alberto;Huang, Gang;Burns, Stephen A.
通讯作者：
Burns, Stephen A.
影响因子：
3.4
作者：
Chang, Hung-Yu;Yazdani, Alireza;Karniadakis, George Em
通讯作者：
Karniadakis, George Em
DOI：
10.1136/bjo.47.9.521
发表时间：
1963-09-01
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
ASHTON, N
通讯作者：
ASHTON, N