Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
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DOI:
10.1016/j.chom.2009.06.006
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发表时间:
2009-07-23
影响因子:
30.3
通讯作者:
Ziegler P
中科院分区:
文献类型:
--
作者:
Legrand N;Ploss A;Balling R;Becker PD;Borsotti C;Brezillon N;Debarry J;de Jong Y;Deng H;Di Santo JP;Eisenbarth S;Eynon E;Flavell RA;Guzman CA;Huntington ND;Kremsdorf D;Manns MP;Manz MG;Mention JJ;Ott M;Rathinam C;Rice CM;Rongvaux A;Stevens S;Spits H;Strick-Marchand H;Takizawa H;van Lent AU;Wang C;Weijer K;Willinger T;Ziegler P
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
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影响因子:
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通讯作者:
Grompe, Markus
影响因子:
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Manz, MG
DOI:
10.1126/science.1160355
发表时间:
2008-07-25
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Grant RM;Hamer D;Hope T;Johnston R;Lange J;Lederman MM;Lieberman J;Miller CJ;Moore JP;Mosier DE;Richman DD;Schooley RT;Springer MS;Veazey RS;Wainberg MA
通讯作者:
Wainberg MA