Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time.
Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time.
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DOI：
10.3390/molecules22030436
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发表时间：
2017-03-09
期刊：
影响因子：
--
通讯作者：
Kobayashi M
中科院分区：
文献类型：
--
作者：
Fuse Y;Kobayashi M
Keap 1-Nrf 2系统是一种进化上保守的抗氧化和外源性胁迫的防御机制。其管理机制，例如，压力感应机制、基于蛋白酶体的Nrf 2活性调节和靶基因的选择主要在哺乳动物中得到阐明。此外，新出现的模式动物，如斑马鱼，果蝇和秀丽隐杆线虫，已被证明具有与哺乳动物相似的抗应激系统，这表明类似的防御系统在整个动物王国中广泛保守。低等动物的实验证据提供了超越实验室局限的实用性的重要信息，例如关于这些系统在进化过程中如何转变的信息，这可能有助于更详细地描述哺乳动物系统。模型动物和非模型动物基因组计划的最新进展为此提供了大量有用的信息。本文综述了Keap 1-Nrf 2及其类似系统在哺乳动物和低等模式动物中的研究进展。此外，通过比较不同物种的Nrf 2和Keap 1蛋白的氨基酸序列，我们可以推断抗应激系统的进化历史。这种结合使用实验和遗传数据的方法将为研究应激反应的研究人员提供方法的观点。
The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against oxidative and xenobiotic stress. Its regulatory mechanisms, e.g., stress-sensing mechanism, proteasome-based regulation of Nrf2 activity and selection of target genes, have been elucidated mainly in mammals. In addition, emerging model animals, such as zebrafish, fruit fly and Caenorhabditis elegans, have been shown to have similar anti-stress systems to mammals, suggesting that analogous defense systems are widely conserved throughout the animal kingdom. Experimental evidence in lower animals provides important information beyond mere laboratory-confined utility, such as regarding how these systems transformed during evolution, which may help characterize the mammalian system in greater detail. Recent advances in genome projects of both model and non-model animals have provided a great deal of useful information toward this end. We herein review the research on Keap1-Nrf2 and its analogous systems in both mammals and lower model animals. In addition, by comparing the amino acid sequences of Nrf2 and Keap1 proteins from various species, we can deduce the evolutionary history of the anti-stress system. This combinatorial approach using both experimental and genetic data will suggest perspectives of approach for researchers studying the stress response.
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
5.3
作者：
Derjuga, A;Gourley, TS;Blank, V
通讯作者：
Blank, V
DOI：
10.1073/pnas.172398899
发表时间：
2002-09-03
影响因子：
11.1
作者：
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通讯作者：
Talalay, P
影响因子：
11.4
作者：
Delaunay, A;Isnard, AD;Toledano, MB
通讯作者：
Toledano, MB
一种基于多功能φC31的记者系统，用于测量果蝇和组织培养中的AP-1和NRF2信号传导。
影响因子：
3.7
作者：
Chatterjee N;Bohmann D
通讯作者：
Bohmann D