The African coelacanth genome provides insights into tetrapod evolution.
The African coelacanth genome provides insights into tetrapod evolution.
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1938年首次发现腔棘鱼的活标本时，这是一个动物学上的轰动，因为这种叶鳍鱼的血统被认为在7000万年前就灭绝了。现代的腔棘鱼看起来与它的许多古代亲戚非常相似，它与我们自己的鱼类祖先的进化接近提供了第一次在陆地上行走的鱼类的一瞥。在这里，我们报告的基因组序列的非洲腔棘鱼，Latimeria chalumanus。通过基因组分析，我们得出结论，肺鱼，而不是腔棘鱼，是四足动物最近的生活亲戚。与其他基因组特征不同，腔棘鱼蛋白质编码基因的进化比四足动物的进化要慢得多。对脊椎动物适应陆地过程中基因和调控元件变化的分析突出了与免疫、氮排泄以及鳍、尾、耳、眼、脑和嗅觉发育有关的基因。参与鳍肢过渡和胚胎外组织的出现的增强子的功能测定证明了腔棘鱼基因组作为理解四足动物进化蓝图的重要性。
It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features . Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain, and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues demonstrate the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.
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DOI：
10.1002/jez.b.22455
发表时间：
2012-07-01
影响因子：
2.2
作者：
Canapa, Adriana;Olmo, Ettore;Barucca, Marco
通讯作者：
Barucca, Marco
影响因子：
64.8
作者：
Jones, Felicity C.;Grabherr, Manfred G.;Chan, Yingguang Frank;Russell, Pamela;Mauceli, Evan;Johnson, Jeremy;Swofford, Ross;Pirun, Mono;Zody, Michael C.;White, Simon;Birney, Ewan;Searle, Stephen;Schmutz, Jeremy;Grimwood, Jane;Dickson, Mark C.;Myers, Richard M.;Miller, Craig T.;Summers, Brian R.;Knecht, Anne K.;Brady, Shannon D.;Zhang, Haili;Pollen, Alex A.;Howes, Timothy;Amemiya, Chris;Lander, Eric S.;Di Palma, Federica;Lindblad-Toh, Kerstin;Kingsley, David M.
通讯作者：
Kingsley, David M.
影响因子：
2.7
作者：
Navratilova, Pavia;Fredman, David;Becker, Thomas S.
通讯作者：
Becker, Thomas S.
DOI：
10.1073/pnas.0538029100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Ota, T;Rast, JP;Amemiya, CT
通讯作者：
Amemiya, CT
影响因子：
7
作者：
Cantarel, Brandi L.;Korf, Ian;Yandell, Mark
通讯作者：
Yandell, Mark