Non-Coding RNAs Regulate Spontaneous Abortion: A Global Network and System Perspective.

Non-Coding RNAs Regulate Spontaneous Abortion: A Global Network and System Perspective.
复制标题

非编码RNA调节自发性流产:全球网络和系统视角

DOI:
10.3390/ijms23084214
复制
发表时间:
2022-04-11
影响因子:
5.6
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
作者:

文献摘要

参考文献

被引文献

相似文献

自然流产是一种常见的妊娠并发症,对妇女健康和商品猪生产产生负面影响。研究表明,非编码RNA (ncRNA)通过影响细胞增殖、侵袭、凋亡、上皮-间充质转化(EMT)、迁移和免疫应答参与了SA的发生。在过去的十年中,对SA中ncRNAs的研究主要集中在微rna (miRNAs)、长链非编码rna (lncRNAs)和环状rna (circRNAs)上。在这篇综述中,我们讨论了最近的ncRNA研究,重点是mirna、lncrna和circrna在调节SA中的功能和机制。同时,我们认为在SA的发生和发展过程中存在ceRNA调控网络。对这一网络的深入了解将加速寻找潜在的RNA标记物用于SA诊断和治疗的过程。
Spontaneous abortion is a common pregnancy complication that negatively impacts women’s health and commercial pig production. It has been demonstrated that non-coding RNA (ncRNA) is involved in SA by affecting cell proliferation, invasion, apoptosis, epithelial-mesenchymal transformation (EMT), migration, and immune response. Over the last decade, research on ncRNAs in SA has primarily concentrated on micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In this review, we discuss recent ncRNA studies focused on the function and mechanism of miRNAs, lncRNAs, and circRNAs in regulating SA. Meanwhile, we suggest that a ceRNA regulatory network exists in the onset and development of SA. A deeper understanding of this network will accelerate the process of the quest for potential RNA markers for SA diagnosis and treatment.
DOI: 10.1038/nature07242
发表时间: 2008-09-04
期刊: NATURE
影响因子: 64.8
作者:
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者: Bartel, David P.
M1巨噬细胞衍生的细胞外囊泡传递miR-146a-5p和miR-146b-5p,通过靶向TRAF6抑制复发性流产中的滋养层细胞迁移和侵袭
DOI: 10.7150/thno.58731
发表时间: 2021
期刊: Theranostics
影响因子: 12.4
作者:
Ding J;Zhang Y;Cai X;Zhang Y;Yan S;Wang J;Zhang S;Yin T;Yang C;Yang J
通讯作者: Yang J
DOI: 10.1126/science.1240925
发表时间: 2013-08-16
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者: Fitzgerald KA
DOI: 10.3389/fmolb.2021.652250
发表时间: 2021
影响因子: 5
作者:
Chen D;He B;Zheng P;Wang S;Zhao X;Liu J;Yang X;Cheng W
通讯作者: Cheng W
DOI: 10.3390/ijms131216708
发表时间: 2012-12-06
影响因子: 5.6
作者:
Baldassarre A;Masotti A
通讯作者: Masotti A