Chemical material basis study of Xuefu Zhuyu decoction by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Chemical material basis study of Xuefu Zhuyu decoction by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
复制标题
超高效液相色谱-四极杆飞行时间质谱法研究血府逐瘀汤的化学物质基础
DOI：
10.1016/j.jfda.2015.06.004
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发表时间：
2015-12
影响因子：
3.6
通讯作者：
Chai, Xin
中科院分区：
文献类型：
--
作者：
Zhang, Lei;Jiang, Zhenzuo;Yang, Jing;Li, Yuanyuan;Wang, Yuefei;Chai, Xin
关键词：
血府逐瘀汤是中医经典方剂，在临床上广泛应用于心脑血管疾病的治疗。为了剖析该方的化学物质基础，建立了超高效液相色谱（UPLC）与四极杆飞行时间质谱（Q/TOF MS）联用的方法，用于快速分离和结构表征。结果表明，共检测到酚酸类、精脒类、C-糖基喹查尔酮类、萜类、黄酮类、皂苷类等103种化合物，其中35种化合物已明确鉴定，通过比较保留时间、质谱数据、特征质谱裂解模式和检索文献，初步鉴定了68种化合物。结论：UPLC-四极杆飞行时间质谱联用技术是中药方剂化学物质基础研究的有效方法。
Xuefu Zhuyu decoction, a classic prescription in traditional Chinese medicine, has been widely used in the clinical treatment of cardiovascular and cerebrovascular diseases. In order to profile the chemical material basis of this formula, an ultra-performance liquid chromatography (UPLC) coupled with quadrupole time-of-flight mass spectrometry (Q/TOF MS) method has been established for rapid separation and structural characterization of compounds in the decoction. As a result, 103 compounds including phenolic acids, spermidines, C-glycosyl quinochalcones, terpenoids, flavonoids, saponins, and others were detected; 35 of them were unambiguously identified, and 68 were tentatively characterized by comparing the retention time, MS data, characteristic MS fragmentation pattern and retrieving the literature. In conclusion, the UPLC coupled with quadrupole time-of-flight mass spectrometry method developed in this work is an efficient approach to perform chemical material basis studies of traditional Chinese medicine formulae.
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影响因子：
2.9
作者：
Gao Dong;Wu Li-ya;Jiao Yu-huan;Chen Wen-yuan;Chen Yan;Kaptchuk, Ted J.;Lu Bo;Song Jun;Chen Ke-ji
通讯作者：
Chen Ke-ji
DOI：
10.1016/j.jpba.2007.10.036
发表时间：
2008-02-13
影响因子：
3.4
作者：
Jin, Yu;Xiao, Yuan-sheng;Liang, Xin-miao
通讯作者：
Liang, Xin-miao
影响因子：
5.4
作者：
Lee, Jie-Jen;Hsu, Wen-Hsien;Sheu, Joen-Rong
通讯作者：
Sheu, Joen-Rong
影响因子：
1.7
作者：
Jiang, Jian-Shuang;Lue, Liang;Zhang, Pei-Cheng
通讯作者：
Zhang, Pei-Cheng
影响因子：
2
作者：
Zheng, Yun-Feng;Qi, Lian-Wen;Li, Ping
通讯作者：
Li, Ping