Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children.
Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children.
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怀孕期间的孕产妇抑郁症和脐带血DNA甲基化：来自父母和孩子的Avon纵向研究的发现。
DOI：
10.1038/s41398-018-0286-4
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发表时间：
2018-11-07
影响因子：
6.8
通讯作者：
Relton CL
中科院分区：
文献类型：
--
作者：
Viuff AC;Sharp GC;Rai D;Henriksen TB;Pedersen LH;Kyng KJ;Staunstrup NH;Cortes A;Neumann A;Felix JF;Tiemeier H;Jaddoe VWV;Relton CL
多达13%的女性可能会在怀孕期间或产后出现抑郁症状。怀孕期间的抑郁症与儿童不良神经发育结果的风险增加有关，表观遗传机制可能是解释这种关联的生物学途径之一。在雅芳父母和孩子纵向研究的844对母子中，我们进行了一项表观基因组关联研究（EWAS），以调查前瞻性收集的关于母亲抑郁症的数据（由爱丁堡产后抑郁量表确定）与新生儿脐带血中DNA甲基化之间的关联。在个体位点分析中，我们确定了两个与妊娠中期母亲抑郁相关的CpG位点。在我们的区域分析中，我们确定了39个差异甲基化区域（DMR）。7例DMR与妊娠期间任何时间点的抑郁症相关，7例与妊娠中期抑郁症相关，23例与妊娠晚期抑郁症相关，2例DMR与整个妊娠期抑郁症相关。其中一些基因与精神疾病和大脑发育有关。我们试图在R世代研究中进行重复，但无法复制我们的结果。虽然我们在ALSPAC的研究结果表明，母亲抑郁症可能与脐带血DNA甲基化有关，但该结果应被视为初步的假设，直到在更大的样本中进一步复制。
Up to 13% of women may experience symptoms of depression during pregnancy or in the postpartum period. Depression during pregnancy has been associated with an increased risk of adverse neurodevelopmental outcomes in the child and epigenetic mechanisms could be one of the biological pathways to explain this association. In 844 mother–child pairs from the Avon Longitudinal Study of Parents and Children, we carried out an epigenome-wide association study (EWAS) to investigate associations between prospectively collected data on maternal depression ascertained by the Edinburgh Postnatal Depression Scale in pregnancy and DNA methylation in the cord blood of newborn offspring. In individual site analysis, we identified two CpG sites associated with maternal depression in the middle part of pregnancy. In our regional analysis, we identified 39 differentially methylated regions (DMRs). Seven DMRs were associated with depression at any time point during pregnancy, 7 associated with depression in mid-pregnancy, 23 were associated with depression in late pregnancy, and 2 DMRs were associated with depression throughout pregnancy. Several of these map to genes associated with psychiatric disease and brain development. We attempted replication in The Generation R Study and could not replicate our results. Although our findings in ALSPAC suggest that maternal depression could be associated with cord blood DNA methylation the results should be viewed as preliminary and hypothesis generating until further replicated in a larger sample.
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影响因子：
4.4
作者：
Bibikova, Marina;Barnes, Bret;Shen, Richard
通讯作者：
Shen, Richard
DOI：
10.3390/healthcare3041212
发表时间：
2015-11-26
期刊：
Healthcare (Basel, Switzerland)
影响因子：
--
作者：
Lewis AJ;Austin E;Knapp R;Vaiano T;Galbally M
通讯作者：
Galbally M
影响因子：
9.8
作者：
Joubert, Bonnie R.;Felix, Janine F.;London, Stephanie J.
通讯作者：
London, Stephanie J.
影响因子：
12.3
作者：
Gaunt TR;Shihab HA;Hemani G;Min JL;Woodward G;Lyttleton O;Zheng J;Duggirala A;McArdle WL;Ho K;Ring SM;Evans DM;Davey Smith G;Relton CL
通讯作者：
Relton CL
通过替代变量分析捕获基因表达研究中的异质性。
影响因子：
4.5
作者：
Leek, Jeffrey T.;Storey, John D.
通讯作者：
Storey, John D.