Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells.
Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells.
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令人惊讶的是，皮肤来源的人类成体干细胞与人类胰腺干细胞有许多共同的特征。
DOI：
10.1016/j.ejcb.2007.07.004
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发表时间：
2008
影响因子：
6.6
通讯作者：
S. Danner
中科院分区：
文献类型：
--
作者：
Jennifer Kajahn;E. Gorjup;S. Tiede;H. von Briesen;R. Paus;C. Kruse;S. Danner
人体内的多个组织壁龛现在被认为是干细胞的港湾。在这里，我们已经询问了从两个个体发育不同的人体器官（皮肤，胰腺）分离的成体干细胞群在一组标准标志物/特征方面实际上是如何不同的。在这里，我们表明，一个容易获得的成人人体组织，如皮肤，可以作为一个方便的来源，成人干细胞样群体，共享标记与干细胞来自内部，外分泌器官。令人惊讶的是，人胰腺和皮肤来源的干细胞/祖细胞都显示出跨越谱系边界分化为外胚层（例如PGP 9.5+和GFAP+）、中胚层（例如α-SMA+）和内胚层（例如淀粉酶+和白蛋白+）的细胞类型的分化模式。这种有趣的分化能力保证了系统性随访，因为它提出了理论上的可能性，即成年人皮肤来源的祖细胞群体可以设想用于细胞替代疗法的可能应用。
Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here we show that an easily accessible adult human tissue such as skin may serve as a convenient source of adult stem cell-like populations that share markers with stem cells derived from an internal, exocrine organ. Surprisingly, both, human pancreas- and skin-derived stem/progenitor cells demonstrate differentiation patterns across lineage boundaries into cell types of ectoderm (e.g. PGP 9.5+ and GFAP+), mesoderm (e.g. α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies.
影响因子：
4.7
作者：
Tai, MH;Chang, CC;Trosko, JE
通讯作者：
Trosko, JE
DOI：
10.1073/pnas.97.20.10960
发表时间：
2000-09-26
影响因子：
11.1
作者：
Tani, H;Morris, RJ;Kaur, P
通讯作者：
Kaur, P
影响因子：
6
作者：
Yu, Hong;Fang, Dong;Xu, Xiaowei
通讯作者：
Xu, Xiaowei