Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model.
Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model.
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DOI：
10.1038/s41598-017-12917-z
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发表时间：
2017-10-06
影响因子：
4.6
通讯作者：
Fukui K
中科院分区：
文献类型：
--
作者：
Yoshii T;Oishi N;Ikoma K;Nishimura I;Sakai Y;Matsuda K;Yamada S;Tanaka M;Kawata M;Narumoto J;Fukui K
心理压力会诱发许多疾病，包括创伤后应激障碍（PTSD）；然而，压力与脑萎缩之间的因果关系尚未明确。应用单次长时间应激（SPS）来探究严重应激的整体效应，我们进行了脑部磁共振成像（MRI）采集和基于体素的形态测量学（VBM）。在双侧丘脑和右侧视觉皮层检测到显著萎缩。以Iba - 1作为活化小胶质细胞标志物的荧光免疫组织化学显示，在这些萎缩区域，小胶质细胞出现区域性活化作为应激反应。这些数据证实了严重心理压力对视觉皮层和丘脑萎缩的影响。出乎意料的是，这些结果与慢性神经病理性疼痛相似，而非PTSD临床研究。我们认为，视觉皮层和丘脑因严重应激导致萎缩的某些致敏机制以及视觉系统的功能缺陷可能是应激相关疾病的一个潜在治疗靶点。
Psychological stress induces many diseases including post-traumatic stress disorder (PTSD); however, the causal relationship between stress and brain atrophy has not been clarified. Applying single-prolonged stress (SPS) to explore the global effect of severe stress, we performed brain magnetic resonance imaging (MRI) acquisition and Voxel-based morphometry (VBM). Significant atrophy was detected in the bilateral thalamus and right visual cortex. Fluorescent immunohistochemistry for Iba-1 as the marker of activated microglia indicates regional microglial activation as stress-reaction in these atrophic areas. These data certify the impact of severe psychological stress on the atrophy of the visual cortex and the thalamus. Unexpectedly, these results are similar to chronic neuropathic pain rather than PTSD clinical research. We believe that some sensitisation mechanism from severe stress-induced atrophy in the visual cortex and thalamus, and the functional defect of the visual system may be a potential therapeutic target for stress-related diseases.
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影响因子：
2.1
作者：
Chen SN;Ballantyne CM;Gotto AM Jr;Marian AJ
通讯作者：
Marian AJ
影响因子：
2.9
作者：
Kato TA;Kanba S
通讯作者：
Kanba S
影响因子：
4.4
作者：
Goldstein RB;Smith SM;Chou SP;Saha TD;Jung J;Zhang H;Pickering RP;Ruan WJ;Huang B;Grant BF
通讯作者：
Grant BF
影响因子：
2.3
作者：
Klaver, Roel;De Vries, Helga E.;Geurts, Jeroen J. G.
通讯作者：
Geurts, Jeroen J. G.
影响因子：
10.6
作者：
Kasai, Kiyoto;Yamasue, Hidenori;Pitman, Roger K.
通讯作者：
Pitman, Roger K.