Role of IL-17A and IL-10 in the antigen induced inflammation model by Mycoplasma pneumoniae.
Role of IL-17A and IL-10 in the antigen induced inflammation model by Mycoplasma pneumoniae.
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DOI：
10.1186/1471-2180-14-156
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发表时间：
2014-06-13
期刊：
影响因子：
4.2
通讯作者：
Kamiya S
中科院分区：
文献类型：
--
作者：
Kurata S;Osaki T;Yonezawa H;Arae K;Taguchi H;Kamiya S
肺炎支原体是社区获得性肺炎的病原体之一，常见于年轻患者。肺外并发症类似于自身免疫性疾病，由M。肺炎，最初感染后。其发病机制和病理尚不清楚，但认为过度的宿主免疫反应在支原体肺炎及其肺外并发症的发病中发挥了作用。在这项研究中，我们研究了免疫应答的参与，不包括以前研究过的Th 1和Th 2的参与。本研究采用M.分析肺炎抗原。M.还检测了体外小鼠淋巴细胞Th 17应答中的肺炎抗原。频繁和集中致敏诱导肺炎症的免疫和病理恶化，并诱发肺内IL-17 A和IL-10的产生。M. pneumoniae抗原刺激诱导小鼠淋巴细胞增殖并引起IL-17 A和IL-10的产生。此外，显示在IL-6和TGF-β1存在下IL-17 A和IL-10的产生增加。结果表明，M. pneumoniae抗原在体内和体外均诱导有效的免疫反应并增强Th 17细胞应答，并且Treg和IL-10均参与抑制IL-17 A的产生。这增加了免疫平衡的破坏可能是导致随后发生肺外支原体肺炎的过程的一部分的可能性。
Mycoplasma pneumoniae is one of the causative organisms of community-acquired pneumonia which is found commonly in younger patients. Extrapulmonary complications similar to autoimmune disease are caused by M. pneumoniae following the initial infection. The mechanism and pathology of onset is not clear, but it is considered that excessive host immunoreactions play a part in the onset of mycoplasmal pneumonia and its extrapulmonary complications. In this study, we investigated the participation of the immune response, excluding the participation of Th1 and Th2 which has previously been investigated. In this study, the host immune response of an antigen induced inflammation model using SPF mice repeatedly sensitized with M. pneumoniae antigens was analyzed. The specificity of M. pneumoniae antigens in the Th17 response of murine lymphocytes in vitro was also examined. Frequent and concentrated sensitization induced exacerbation of lung inflammation immunologically and pathologically, and evoked intrapulmonary IL-17A and IL-10 production. M. pneumoniae antigen stimulation induced proliferation of mouse lymphocytes and caused production of IL-17A and IL-10. In addition, it was shown that IL-17A and IL-10 production was increased in the presence of IL-6 and TGF-β1. It was shown that M. pneumoniae antigens induced potent immunoreaction and enhanced the Th17 cell response both in vivo and in vitro, and that both Treg and IL-10 are involved in the suppression of IL-17A production. This raises the possibility that breakdown of the immune balance may be part of the process leading to subsequent development of extrapulmonary mycoplasmal pneumonia.
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影响因子：
5
作者：
FOY, HM;KENNY, GE;GRAYSTON, JT
通讯作者：
GRAYSTON, JT
影响因子：
6.8
作者：
Higashi, Takehiro;Hashimoto, Kumiko;Matsushita, Sho
通讯作者：
Matsushita, Sho
影响因子：
56.9
作者：
CHEN, YH;KUCHROO, VK;WEINER, HL
通讯作者：
WEINER, HL
影响因子：
--
作者：
Nguyen, Cuong Q.;Hu, Min H.;Peck, Ammon B.
通讯作者：
Peck, Ammon B.
DOI：
10.1073/pnas.250476497
发表时间：
2000-12-05
影响因子：
11.1
作者：
Ozinsky, A;Underhill, DM;Aderem, A
通讯作者：
Aderem, A