Frequent gene conversion between human red and green opsin genes
Frequent gene conversion between human red and green opsin genes
复制标题
人类红色和绿色视蛋白基因之间频繁的基因转换
DOI：
10.1007/pl00013147
复制
发表时间：
1998
影响因子：
3.9
通讯作者：
Wen
中科院分区：
文献类型：
--
作者：
Zhongming Zhao;D. Hewett‐Emmett;Wen
为了研究人类X连锁红色和绿色视蛋白基因的进化，比较了这两个基因的大区域的基因组序列。内含子3、4、5和3′侧翼序列的差异显著低于外显子4和5。人类红、绿色视蛋白基因内含子和3′侧翼序列的均质化机制可能是基因转换，这种转换也发生在外显子1和6。在比较的序列中的三个区域（1、3和5）中的每一个中至少发生一个基因转换事件。总之，基因转换经常发生在人类红色和绿色视蛋白基因之间，但是外显子2、3、4和5通过自然选择在两个基因之间保持不同。
To study the evolution of human X-linked red and green opsin genes, genomic sequences in large regions of the two genes were compared. The divergences in introns 3, 4, and 5 and the 3′ flanking sequence of the two genes are significantly lower than those in exons 4 and 5. The homogenization mechanism of introns and the 3′ flanking sequence of human red and green opsin genes is probably gene conversion, which also occurred in exons 1 and 6. At least one gene conversion event occurred in each of three regions (1,3, and 5) in the sequences compared. In conclusion, gene conversion has occurred frequently between human red and green opsin genes, but exons 2, 3, 4, and 5 have been maintained distinct between the two genes by natural selection.
人类红色和绿色视蛋白基因的单倍型多样性：外显子 3 中频繁序列交换的证据。
影响因子：
3.5
作者：
Winderickx,J;Battisti,L;Hibiya,Y;Motulsky,AG;Deeb,SS
通讯作者：
Deeb,SS
高等灵长类动物 X 连锁色觉基因进化中的基因转换和自然选择。
影响因子：
10.7
作者：
Zhou,YH;Li,WH
通讯作者：
Li,WH