Lithium compartmentation in brain by 7Li MRS: effect of total lithium concentration.
Lithium compartmentation in brain by 7Li MRS: effect of total lithium concentration.
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DOI：
10.1002/nbm.2929
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发表时间：
2013-09
影响因子：
2.9
通讯作者：
Pearce, John M.
中科院分区：
文献类型：
--
作者：
Komoroski, Richard A.;Lindquist, Diana M.;Pearce, John M.
关键词：
在以前的工作中，在4.7 T，在体内的大鼠脑内的双指数7 Li横向（T2）自旋弛豫的各个组成部分，初步确定与内部和细胞外锂。在这项工作中的目标是估计李的房室分布的功能，总锂浓度在大脑中的双指数衰减。本文报道了在7 T下，用同位素富集的7 LiCl对大鼠脑进行的局部双指数7 Li T2 MR自旋弛豫研究。此外，评估了使用双指数T2的简单线性插值，以从单个单指数T2衰变估计细胞内Li。细胞内T2为14.8±4.3 ms，细胞外T2为295±61 ms，脑内Li含量范围为37.3 ~ 64.8%，平均54.5±6.7%，与总Li含量无关。细胞内Li浓度的估计值为脑内Li浓度的47 ~ 80%（平均68.3±8.5%），与脑内Li浓度高度相关，单指数估计值比双指数估计值平均高15%。这项工作支持了先前的结论，即大脑中的大部分Li位于细胞内。
In previous work at 4.7 T, the individual components of biexponential 7Li transverse (T2) spin relaxation in rat brain in vivo were tentatively identified with intra- and extracellular Li. The goal in this work was to estimate Li’s compartmental distribution as a function of total Li concentration in brain from the biexponential decays. Here a localized, biexponential 7Li T2 MR spin relaxation study with isotopically enriched 7LiCl is reported in rat brain in vivo at 7 T. Additionally a simple linear interpolation using the biexponential T2s to estimate intracellular Li from individual monoexponential T2 decays was assessed. Intracellular T2 was 14.8±4.3 ms and extracellular T2 was 295±61 ms. The fraction of intracellular brain Li ranged from 37.3 to 64.8% (mean 54.5±6.7%) and did not correlate with total Li concentration. The estimated intracellular Li concentration ranged from 47 to 80% (mean 68.3±8.5%) of the total brain Li concentration and was highly correlated with it. The monoexponential estimates of the intracellular-Li fractions and derived concentrations averaged about 15% higher than the corresponding biexponential estimates. This work supports the previous conclusion that a large fraction of Li in the brain is within the intracellular compartment.
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