Human T‐cell leukemia virus type I: Induction of syncytia and inhibition by patients' sera
Human T‐cell leukemia virus type I: Induction of syncytia and inhibition by patients' sera
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人类 T 细胞白血病病毒 I 型：合胞体的诱导和患者血清的抑制
DOI：
10.1002/ijc.2910320310
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发表时间：
1983
影响因子：
6.4
通讯作者：
R. Weiss
中科院分区：
文献类型：
--
作者：
K. Nagy;P. Clapham;R. Cheingsong;R. Weiss
当与多种指示细胞共培养时，产生HTLV的T细胞系诱导细胞融合，表明HTLV包膜抗原与许多细胞类型的膜相互作用。来自成人T细胞淋巴瘤-白血病（ATL）患者的血清抗体抑制合胞体的形成，来自英国、美国和日本ATL患者的血清同样抑制美国和日本HTLV分离株诱导的细胞融合。在HTLV与牛白血病病毒、莫洛尼鼠白血病病毒和猿猴肉瘤相关病毒之间未发现合胞体诱导的血清学交叉抑制。一个简单的合胞体抑制试验在微量滴定板已开发提供一个快速筛选抗体推测是特异性的HTLV包膜糖蛋白。
HTLV‐producing T‐cell lines induce cell fusion when cocultivated with a wide variety of indicator cells, suggesting that HTLV envelope antigens interact with the membranes of many cell types. Serum antibodies from adult T‐cell lymphoma‐leukemia (ATL) patients inhibited the formation of syncytia, and sera from British, American and Japanese ATL patients inhibited cell fusion induced by American and Japanese HTLV isolates equally well. No serological cross‐inhibition of syncytium induction was found between HTLV and bovine leukosis virus, Moloney murine leukemia virus and simian sarcoma‐associated virus. A simple syncytium inhibition test in microtiter plates has been developed to provide a rapid screen for antibodies presumed to be specific to HTLV envelope glycoproteins.
单克隆抗体选择性中和亲嗜性鼠白血病病毒：gp70蛋白上与亲嗜性相关的位点的定位。
影响因子：
3.7
作者：
Nowinski,RC;Pickering,R;O'Donnell,PV;Pinter,A;Hammerling,U
通讯作者：
Hammerling,U