Selective neutralization of ecotropic murine leukemia virus by monoclonal antibodies: localization of a site on the gp70 protein associated with ecotropism.

Selective neutralization of ecotropic murine leukemia virus by monoclonal antibodies: localization of a site on the gp70 protein associated with ecotropism.
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单克隆抗体选择性中和亲嗜性鼠白血病病毒:gp70蛋白上与亲嗜性相关的位点的定位。

DOI:
10.1016/0042-6822(81)90655-3
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发表时间:
1981
期刊:
影响因子:
3.7
通讯作者:
Hammerling,U
Hammerling,U
中科院分区:
医学3区
文献类型:
--
作者:
Nowinski,RC;Pickering,R;O'Donnell,PV;Pinter,A;Hammerling,U

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一组针对MuLV的gp70和p15(E)包膜蛋白的9个单克隆抗体平行测试了它们与病毒结合和中和传染性的能力。虽然每一种抗体都能与嗜n型MuLV结合,但只有抗gp70fepitope的抗体能中和感染性。这些结果被解释为证明亲生态MuLV的gp70蛋白上有一个特定位点,靠近gp70抗原位,这是负责病毒与细胞表面的亲生态特异性结合的。
A panel of nine monoclonal antibodies against the gp70 and p15(E) envelope proteins of MuLV were tested in parallel for their ability to bind to virus and neutralize infectivity. Although each of the antibodies bound to N-ecotropic MuLV, only antibody against the gp70fepitope neutralized infectivity. These results were interpreted as evidence for a specific site on the gp70 protein of ecotropic MuLV, in proximity of the gp70fepitope, which was responsible for the ecotropic-specific binding of virus to the surface of cells.
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发表时间: 1978
影响因子: 2.9
作者:
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发表时间: 1979-07
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影响因子: 3.7
作者:
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影响因子: 11.2
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DOI: --
发表时间: 1979
期刊: Virology
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