Our Tangled Family Tree: New Genomic Methods Offer Insight into the Legacy of Archaic Admixture.
Our Tangled Family Tree: New Genomic Methods Offer Insight into the Legacy of Archaic Admixture.
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DOI：
10.1093/gbe/evab115
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发表时间：
2021-07-06
影响因子：
3.3
通讯作者：
Witt KE
中科院分区：
文献类型：
--
作者：
Ahlquist KD;Bañuelos MM;Funk A;Lai J;Rong S;Villanea FA;Witt KE
近年来，人类基因组中存在的古老祖先吸引了科学家和广大公众的想象力。这种兴奋是新研究的结果，这些研究推动了我们从人类基因组中存活了5万年的古老遗传信息中所能学到的东西。在这里，我们回顾了最近十年来关于古代基因渗入的文献，包括尼安德特人和丹尼索瓦人基因渗入的知识现状，以及其他尚未确定的古代人群的基因渗入。本文主要讨论四个问题：1）重新构想人类人口统计学史，包括现代人、尼安德特人、丹尼索瓦人和其他古代人群之间多重混合事件的证据; 2）在人群水平基因组数据中检测古代祖先的最新方法; 3）这些新方法如何检测现代非洲人群中的古代渐渗;以及4）古老基因变异的功能后果，包括这些变异如何在现代人群中被增选为新功能。这篇综述的目的是为相关方法和新数据提供一个简单易行的参考，这些方法和数据改变了我们对我们物种与其兄弟姐妹之间关系的理解。这些文献揭示了这些灭绝的人类的遗传遗产在很大程度上已经整合到今天的人类种群中。
The archaic ancestry present in the human genome has captured the imagination of both scientists and the wider public in recent years. This excitement is the result of new studies pushing the envelope of what we can learn from the archaic genetic information that has survived for over 50,000 years in the human genome. Here, we review the most recent ten years of literature on the topic of archaic introgression, including the current state of knowledge on Neanderthal and Denisovan introgression, as well as introgression from other as-yet unidentified archaic populations. We focus this review on four topics: 1) a reimagining of human demographic history, including evidence for multiple admixture events between modern humans, Neanderthals, Denisovans, and other archaic populations; 2) state-of-the-art methods for detecting archaic ancestry in population-level genomic data; 3) how these novel methods can detect archaic introgression in modern African populations; and 4) the functional consequences of archaic gene variants, including how those variants were co-opted into novel function in modern human populations. The goal of this review is to provide a simple-to-access reference for the relevant methods and novel data, which has changed our understanding of the relationship between our species and its siblings. This body of literature reveals the large degree to which the genetic legacy of these extinct hominins has been integrated into the human populations of today.
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影响因子：
9.8
作者：
Dannemann M;Kelso J
通讯作者：
Kelso J
影响因子：
64.8
作者：
Findlay GM;Daza RM;Martin B;Zhang MD;Leith AP;Gasperini M;Janizek JD;Huang X;Starita LM;Shendure J
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Shendure J
影响因子：
3.3
作者：
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通讯作者：
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16.8
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通讯作者：
Capra, John A.
影响因子：
64.5
作者：
Browning SR;Browning BL;Zhou Y;Tucci S;Akey JM
通讯作者：
Akey JM