Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.
Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.
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DOI：
10.1016/j.cell.2018.02.031
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发表时间：
2018-03-22
期刊：
影响因子：
64.5
通讯作者：
Akey JM
中科院分区：
文献类型：
--
作者：
Browning SR;Browning BL;Zhou Y;Tucci S;Akey JM
从解剖学上讲，现代人与尼安德特人以及与之相关的古代人口丹尼索瓦人杂交。几个尼安德特人和一个丹尼索瓦人的基因组已经被测序，这些参考基因组已被用于检测当今人类基因组中渗入的遗传物质。也可以在不使用参考基因组的情况下检测基因渗入的区段，这对于发现与测序的古老基因组不太密切相关的基因渗入区段可能是有利的。我们应用一种新的无参考方法检测来自欧亚大陆和大洋洲的5639个全基因组序列的古老渐渗。我们在东亚、南亚和巴布亚人中发现了丹尼索瓦人的祖先。丹尼索瓦人的祖先由两个组成部分组成，与已测序的阿尔泰丹尼索瓦人个体具有不同的相似性。这表明至少发生了两种不同的丹尼索瓦人混合到现代人类中的情况，涉及与已测序的阿尔泰丹尼索瓦人具有不同程度相关性的丹尼索瓦人群体。
Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one Denisovan have been sequenced, and these reference genomes have been used to detect introgressed genetic material in present-day human genomes. Segments of introgression can also be detected without use of reference genomes, which can be advantageous for finding introgressed segments that are less closely related to the sequenced archaic genomes. We apply a new reference-free method for detecting archaic introgression to 5639 whole genome sequences from Eurasia and Oceania. We find Denisovan ancestry in populations from East and South Asia, and in Papuans. The Denisovan ancestry is comprised of two components with differing similarity to the sequenced Altai Denisovan individual. This indicates that at least two distinct instances of Denisovan admixture into modern humans occurred, involving Denisovan populations that had different levels of relatedness to the sequenced Altai Denisovan.
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影响因子：
4.5
作者：
Gutenkunst RN;Hernandez RD;Williamson SH;Bustamante CD
通讯作者：
Bustamante CD
DOI：
10.1126/science.1224344
发表时间：
2012-10-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Meyer M;Kircher M;Gansauge MT;Li H;Racimo F;Mallick S;Schraiber JG;Jay F;Prüfer K;de Filippo C;Sudmant PH;Alkan C;Fu Q;Do R;Rohland N;Tandon A;Siebauer M;Green RE;Bryc K;Briggs AW;Stenzel U;Dabney J;Shendure J;Kitzman J;Hammer MF;Shunkov MV;Derevianko AP;Patterson N;Andrés AM;Eichler EE;Slatkin M;Reich D;Kelso J;Pääbo S
通讯作者：
Pääbo S
影响因子：
4.5
作者：
Plagnol, Vincent;Wall, Jeffrey D.
通讯作者：
Wall, Jeffrey D.
影响因子：
64.8
作者：
Mallick, Swapan;Li, Heng;Lipson, Mark;Mathieson, Iain;Gymrek, Melissa;Racimo, Fernando;Zhao, Mengyao;Chennagiri, Niru;Nordenfelt, Susanne;Tandon, Arti;Skoglund, Pontus;Lazaridis, Iosif;Sankararaman, Sriram;Fu, Qiaomei;Rohland, Nadin;Renaud, Gabriel;Erlich, Yaniv;Willems, Thomas;Gallo, Carla;Spence, Jeffrey P.;Song, Yun S.;Poletti, Giovanni;Balloux, Francois;van Driem, George;de Knijff, Peter;Romero, Irene Gallego;Jha, Aashish R.;Behar, Doron M.;Bravi, Claudio M.;Capelli, Cristian;Hervig, Tor;Moreno-Estrada, Andres;Posukh, Olga L.;Balanovska, Elena;Balanovsky, Oleg;Karachanak-Yankova, Sena;Sahakyan, Hovhannes;Toncheva, Draga;Yepiskoposyan, Levon;Tyler-Smith, Chris;Xue, Yali;Abdullah, M. Syafiq;Ruiz-Linares, Andres;Beall, Cynthia M.;Di Rienzo, Anna;Jeong, Choongwon;Starikovskaya, Elena B.;Metspalu, Ene;Parik, Juri;Villems, Richard;Henn, Brenna M.;Hodoglugil, Ugur;Mahley, Robert;Sajantila, Antti;Stamatoyannopoulos, George;Wee, Joseph T. S.;Khusainova, Rita;Khusnutdinova, Elza;Litvinov, Sergey;Ayodo, George;Comas, David;Hammer, Michael F.;Kivisild, Toomas;Klitz, William;Winkler, Cheryl A.;Labuda, Damian;Bamshad, Michael;Jorde, Lynn B.;Tishkoff, Sarah A.;Watkins, W. Scott;Metspalu, Mait;Dryomov, Stanislav;Sukernik, Rem;Singh, Lalji;Thangaraj, Kumarasamy;Paeaebo, Svante;Kelso, Janet;Patterson, Nick;Reich, David
通讯作者：
Reich, David
影响因子：
4.3
作者：
Kelleher J;Etheridge AM;McVean G
通讯作者：
McVean G