Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection.
Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection.
复制标题
DOI：
10.1155/2018/4315140
复制
发表时间：
2018
影响因子：
4.1
通讯作者：
Knoell DL
中科院分区：
文献类型：
--
作者：
Sapkota M;Knoell DL
锌是一种必需的微量营养素，已知在宿主防御病原体中起着至关重要的作用。缺乏锌的饮食会导致免疫力受损，感染后恢复延迟和更差的结果。持续的锌摄入不足导致先天免疫反应失调，增加感染的易感性，而在高危人群中补充锌已被证明可以恢复宿主防御，降低病原体相关的发病率和死亡率。在感染后，由于关键信号网络的不平衡，锌缺乏导致病理学增加，导致过度炎症和附带组织损伤。特别是，锌影响巨噬细胞功能，这是宿主防御中的关键前线细胞，以及其他免疫细胞。锌缺乏对巨噬细胞功能产生不利影响，导致吞噬作用、细胞内杀伤和细胞因子产生失调。该领域的另一项工作揭示了几种锌转运蛋白的重要作用，这些蛋白是单核细胞内锌的适当生物分布所需的，以实现对入侵微生物的最佳免疫应答。在这篇综述中，我们将讨论锌在先天免疫和抵御病原体入侵中的作用的最新进展。
Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key signaling networks that result in excessive inflammation and collateral tissue damage. In particular, zinc impacts macrophage function, a critical front-line cell in host defense, in addition to other immune cells. Deficits in zinc adversely impact macrophage function resulting in dysregulation of phagocytosis, intracellular killing, and cytokine production. An additional work in this field has revealed a vital role for several zinc transporter proteins that are required for proper bioredistribution of zinc within mononuclear cells to achieve an optimal immune response against invading microorganisms. In this review, we will discuss the most recent developments regarding zinc's role in innate immunity and protection against pathogen invasion.
登录
查看更多内容
金属转运蛋白 Slc39a10 通过控制巨噬细胞存活来调节对炎症刺激的敏感性
DOI：
10.1073/pnas.1708018114
发表时间：
2017-12-05
影响因子：
11.1
作者：
Gao H;Zhao L;Wang H;Xie E;Wang X;Wu Q;Yu Y;He X;Ji H;Rink L;Min J;Wang F
通讯作者：
Wang F
锌信号在免疫系统中的作用。
影响因子：
4.1
作者：
Hojyo S;Fukada T
通讯作者：
Fukada T
影响因子：
5.9
作者：
Gammoh NZ;Rink L
通讯作者：
Rink L
影响因子：
2.2
作者：
Gálvez-Peralta M;Wang Z;Bao S;Knoell DL;Nebert DW
通讯作者：
Nebert DW
DOI：
10.1016/s0006-291x(02)02017-x
发表时间：
2002-08-30
影响因子：
3.1
作者：
Haase, H;Beyersmann, D
通讯作者：
Beyersmann, D