Bidirectional Introgression between Mus musculus domesticus and Mus spretus.
Bidirectional Introgression between Mus musculus domesticus and Mus spretus.
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DOI：
10.1093/gbe/evab288
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发表时间：
2022-01-04
影响因子：
3.3
通讯作者：
Nachman MW
中科院分区：
文献类型：
--
作者：
Banker SE;Bonhomme F;Nachman MW
来自其他物种的渗入变体可能是遗传变异的重要来源，因为它们可能迅速出现，可以在单个单倍型上包含多个突变，并且通常通过在起源物种中进行选择来进行预先测试。虽然基因渗入通常是有害的，但一些研究报告基因渗入是适应性等位基因的来源，包括从 Mus spretus 基因渗入欧洲家鼠种群的 Vkorc1 抗啮齿动物剂变体。在这里，我们进行了双向基因组扫描，以表征来自西班牙的 M. spretus 的一个野生种群和 M. m. 的三个野生种群的渐渗区域。法国、德国和伊朗的家蝇。尽管这些物种表现出相当大的内在合子后生殖隔离，但在所有个体中都观察到基因渗入，包括在小家鼠参考基因组 (GRCm38) 中。与小家鼠 (Mus spretus) 相比，小家鼠 (Mus spretus) 个体的基因渗入比例更大。家畜，并在 M. m. 内。在家蝇中，基因渗入的比例随着距同源区域的地理距离而降低。在这两个物种的所有常染色体上都观察到基因渗入，但在 M. m 的 X 染色体上没有观察到基因渗入。与已知的 X 连锁杂种不育和不活基因一致，这些基因已被定位到 M. spretus X 染色体。束长度普遍较短，有一些异常值高达 2.7 Mb。有趣的是，最长的渐渗束位于嗅觉受体区域，并且两个物种中渐渗束的嗅觉受体基因显着富集，这表明即使在基因流动具有高障碍的物种之间，渐渗也可能是功能新颖性的来源。
Introgressed variants from other species can be an important source of genetic variation because they may arise rapidly, can include multiple mutations on a single haplotype, and have often been pretested by selection in the species of origin. Although introgressed alleles are generally deleterious, several studies have reported introgression as the source of adaptive alleles—including the rodenticide-resistant variant of Vkorc1 that introgressed from Mus spretus into European populations of Mus musculus domesticus. Here, we conducted bidirectional genome scans to characterize introgressed regions into one wild population of M. spretus from Spain and three wild populations of M. m. domesticus from France, Germany, and Iran. Despite the fact that these species show considerable intrinsic postzygotic reproductive isolation, introgression was observed in all individuals, including in the M. musculus reference genome (GRCm38). Mus spretus individuals had a greater proportion of introgression compared with M. m. domesticus, and within M. m. domesticus, the proportion of introgression decreased with geographic distance from the area of sympatry. Introgression was observed on all autosomes for both species, but not on the X-chromosome in M. m. domesticus, consistent with known X-linked hybrid sterility and inviability genes that have been mapped to the M. spretus X-chromosome. Tract lengths were generally short with a few outliers of up to 2.7 Mb. Interestingly, the longest introgressed tracts were in olfactory receptor regions, and introgressed tracts were significantly enriched for olfactory receptor genes in both species, suggesting that introgression may be a source of functional novelty even between species with high barriers to gene flow.
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影响因子：
64.8
作者：
Dasmahapatra, Kanchon K.;Walters, James R.;Briscoe, Adriana D.;Davey, John W.;Whibley, Annabel;Nadeau, Nicola J.;Zimin, Aleksey V.;Hughes, Daniel S. T.;Ferguson, Laura C.;Martin, Simon H.;Salazar, Camilo;Lewis, James J.;Adler, Sebastian;Ahn, Seung-Joon;Baker, Dean A.;Baxter, Simon W.;Chamberlain, Nicola L.;Chauhan, Ritika;Counterman, Brian A.;Dalmay, Tamas;Gilbert, Lawrence E.;Gordon, Karl;Heckel, David G.;Hines, Heather M.;Hoff, Katharina J.;Holland, Peter W. H.;Jacquin-Joly, Emmanuelle;Jiggins, Francis M.;Jones, Robert T.;Kapan, Durrell D.;Kersey, Paul;Lamas, Gerardo;Lawson, Daniel;Mapleson, Daniel;Maroja, Luana S.;Martin, Arnaud;Moxon, Simon;Palmer, William J.;Papa, Riccardo;Papanicolaou, Alexie;Pauchet, Yannick;Ray, David A.;Rosser, Neil;Salzberg, Steven L.;Supple, Megan A.;Surridge, Alison;Tenger-Trolander, Ayse;Vogel, Heiko;Wilkinson, Paul A.;Wilson, Derek;Yorke, James A.;Yuan, Furong;Balmuth, Alexi L.;Eland, Cathlene;Gharbi, Karim;Thomson, Marian;Gibbs, Richard A.;Han, Yi;Jayaseelan, Joy C.;Kovar, Christie;Mathew, Tittu;Muzny, Donna M.;Ongeri, Fiona;Pu, Ling-Ling;Qu, Jiaxin;Thornton, Rebecca L.;Worley, Kim C.;Wu, Yuan-Qing;Linares, Mauricio;Blaxter, Mark L.;Ffrench-Constant, Richard H.;Joron, Mathieu;Kronforst, Marcus R.;Mullen, Sean P.;Reed, Robert D.;Scherer, Steven E.;Richards, Stephen;Mallet, James;McMillan, W. Owen;Jiggins, Chris D.
通讯作者：
Jiggins, Chris D.
DOI：
10.1007/bf01922917
发表时间：
1978-01-01
期刊：
EXPERIENTIA
影响因子：
--
作者：
BONHOMME, F;MARTIN, S;THALER, L
通讯作者：
THALER, L
DOI：
10.1017/s001667230100547x
发表时间：
2002-02-01
期刊：
GENETICAL RESEARCH
影响因子：
--
作者：
Berticat, C;Boquien, G;Chevillon, C
通讯作者：
Chevillon, C
影响因子：
1.5
作者：
GUENET, JL;NAGAMINE, C;BONHOMME, F
通讯作者：
BONHOMME, F
影响因子：
4.9
作者：
Geraldes A;Basset P;Smith KL;Nachman MW
通讯作者：
Nachman MW