Infection With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated With Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals.
Infection With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated With Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals.
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DOI：
10.1093/cid/ciab986
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发表时间：
2022-08-24
期刊：
影响因子：
--
通讯作者：
Mostafa HH
中科院分区：
文献类型：
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作者：
Huai Luo C;Paul Morris C;Sachithanandham J;Amadi A;Gaston DC;Li M;Swanson NJ;Schwartz M;Klein EY;Pekosz A;Mostafa HH
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）关注变体（VOC）B.1.617.2（Delta）取代了B.1.1.7（Alpha），与2019冠状病毒病（COVID-19）病例增加、传播性更强和病毒RNA载量更高相关，但缺乏关于感染性病毒载量和鼻道抗病毒抗体水平的数据。将全基因组测序、循环阈值（Ct）值、感染性病毒、抗SARS-CoV-2免疫球蛋白G（IgG）水平和临床图表审查相结合，以表征2021年1月至9月期间在国家首都地区传播的SARS-CoV-2谱系，并通过Delta、Alpha、和B.1.2（在Alpha之前的主要谱系）变体。到2021年8月，Delta变体取代Alpha变体，占国家首都地区流通血统的99%。在Delta感染中，28.5%是完全接种疫苗的个体中的突破性病例，而Alpha感染队列中为4%。两个队列中的突破性感染均与合并症相关，但仅Delta感染与接种后中位天数显著增加相关。超过74%的Delta样本具有感染性病毒，而Alpha队列的感染率<30%。两种变异体感染性病毒的恢复与当地SARS-CoV-2 IgG的低水平相关。与α变体相比，Delta变体感染与接种疫苗和未接种疫苗的个体中感染性病毒的更频繁恢复相关，但与完全接种疫苗的个体中疾病严重程度的增加无关。感染性病毒与鼻标本中存在少量抗病毒IgG相关。Delta变体取代了Alpha，并与症状性突破性感染增加相关。在接种组和未接种组中，Delta的感染性病毒回收率显著较高。感染性病毒的恢复与下呼吸道IgG水平相关。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) B.1.617.2 (Delta) displaced B.1.1.7 (Alpha) and is associated with increases in coronavirus disease 2019 (COVID-19) cases, greater transmissibility, and higher viral RNA loads, but data are lacking regarding the infectious virus load and antiviral antibody levels in the nasal tract. Whole genome sequencing, cycle threshold (Ct) values, infectious virus, anti-SARS-CoV-2 immunoglobulin G (IgG) levels, and clinical chart reviews were combined to characterize SARS-CoV-2 lineages circulating in the National Capital Region between January and September 2021 and differentiate infections in vaccinated and unvaccinated individuals by the Delta, Alpha, and B.1.2 (the predominant lineage prior to Alpha) variants. The Delta variant displaced the Alpha variant to constitute 99% of the circulating lineages in the National Capital Region by August 2021. In Delta infections, 28.5% were breakthrough cases in fully vaccinated individuals compared to 4% in the Alpha infected cohort. Breakthrough infections in both cohorts were associated with comorbidities, but only Delta infections were associated with a significant increase in the median days after vaccination. More than 74% of Delta samples had infectious virus compared to <30% from the Alpha cohort. The recovery of infectious virus with both variants was associated with low levels of local SARS-CoV-2 IgG. Infection with the Delta variant was associated with more frequent recovery of infectious virus in vaccinated and unvaccinated individuals compared to the Alpha variant but was not associated with an increase in disease severity in fully vaccinated individuals. Infectious virus was correlated with the presence of low amounts of antiviral IgG in the nasal specimens. The Delta variant displaced the Alpha and associated with increased symptomatic breakthrough infections. The recovery of infectious virus was significantly higher with the Delta in both vaccinated and unvaccinated groups. Recovery of infectious virus correlated with lower respiratory IgG levels.
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DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
DOI：
10.3390/v13071192
发表时间：
2021-06-22
期刊：
Viruses
影响因子：
--
作者：
Lazarevic I;Pravica V;Miljanovic D;Cupic M
通讯作者：
Cupic M
影响因子：
9.4
作者：
Mostafa HH;Carroll KC;Hicken R;Berry GJ;Manji R;Smith E;Rakeman JL;Fowler RC;Leelawong M;Butler-Wu SM;Quintero D;Umali-Wilcox M;Kwiatkowski RW;Persing DH;Weir F;Loeffelholz MJ
通讯作者：
Loeffelholz MJ
DOI：
10.1093/cid/ciaa1616
发表时间：
2021-08-16
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Gniazdowski V;Paul Morris C;Wohl S;Mehoke T;Ramakrishnan S;Thielen P;Powell H;Smith B;Armstrong DT;Herrera M;Reifsnyder C;Sevdali M;Carroll KC;Pekosz A;Mostafa HH
通讯作者：
Mostafa HH
影响因子：
64.8
作者：
通讯作者：
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