Pediatric Participant Retention Rates in a Longitudinal Malaria Immunology Study.
Pediatric Participant Retention Rates in a Longitudinal Malaria Immunology Study.
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DOI：
10.4269/ajtmh.21-1052
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发表时间：
2022-04-18
影响因子：
3.3
通讯作者：
Ong'echa, John Michael
中科院分区：
文献类型：
--
作者：
Mistry, Anushay;Odwar, Boaz;Olewe, Fredrick;Kurtis, Jonathan;Moormann, Ann M.;Ong'echa, John Michael
耐药恶性疟原虫的死灰复燃继续促使研制安全有效的疟疾疫苗。自然获得性免疫（NAI）的免疫流行病学研究已成为确定新的疟疾疫苗靶点的有用策略。然而，在整个纵向研究中保留儿科参与者对于收集全面的暴露和结果数据至关重要。在一项为期3年的队列研究（N = 400）的背景下，我们进行了定性调查，以评估影响参与者保留的因素。该研究包括每月手指穿刺和两年一次的静脉血样本采集。第一阶段于2018年7月入组后3个月进行，第二阶段于12个月后进行。在第1阶段，236名家长/监护人参加了焦点小组，3名退出参与者和10名社区卫生志愿者（chv）参加了关键信息提供者访谈。定性分析表明对研究总体满意，61.8%（136/220）的受访者表示不担心。焦点小组讨论者将出席会议与改善获得全面保健服务的机会等福利联系起来。社区卫生志愿者报告说，他们对村子里有关不适当使用血液样本的谣言以及与静脉血抽取有关的危险感到担忧。第2阶段涉及205名家长/监护人，并显示出持续的满意度，46.3%（95/205）表示没有担忧，但对静脉血样本量表示越来越担心。当安排静脉血样本时，错过访问的增加反映了这种担忧。未来的研究将解决家长的担忧，以确定社区参与和教育措施是否会增加学习时间，直到完成学业。
The resurgence of drug-resistant Plasmodium falciparum parasites continues to motivate the development of a safe and efficacious malaria vaccine. Immuno-epidemiologic studies of naturally acquired immunity (NAI) have been a useful strategy to identify new malaria vaccine targets. However, retention of pediatric participants throughout longitudinal studies is essential for gathering comprehensive exposure and outcome data. Within the context of a 3-year cohort (N = 400) study involving monthly finger prick and bi-annual venous blood sample collections, we conducted qualitative surveys to assess factors impacting participant retention. Phase 1 was conducted 3 months after enrollment in July 2018 and phase 2, 12 months later. In phase 1, 236 parents/guardians participated in focus groups and three withdrawn participants and 10 community health volunteers (CHVs) in key informant interviews. Qualitative analysis indicated overall satisfaction with the study, with 61.8% (136/220 respondents) reporting no concerns. Focus group discussants associated attendance with benefits such as improved access to comprehensive healthcare services. Community health volunteers reported concerns over village rumors of inappropriate use of blood samples and dangers associated with venous blood draws. Phase 2 involved 205 parents/guardians and revealed continued satisfaction, with 46.3% (95/205) identifying no concerns, but expressed increasing worries regarding the amount of venous blood sample. This concern was reflected in an uptick of missed visits when venous blood samples were scheduled. Future studies will address parental concerns to determine whether community engagement and education measures increase study retention until completion.
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影响因子：
6.4
作者：
Carter, Rosalind J.;Senesi, Reynold G. B.;Luman, Elizabeth T.
通讯作者：
Luman, Elizabeth T.
影响因子：
2.2
作者：
Gappoo, Sharika;Montgomery, Elizabeth T.;Ramjee, Gita
通讯作者：
Ramjee, Gita
影响因子：
158.5
作者：
Mian-McCarthy, Sara;Agnandji, Selidji Todagbe;Vansadia, Preeti
通讯作者：
Vansadia, Preeti
影响因子：
4
作者：
Abshire M;Dinglas VD;Cajita MI;Eakin MN;Needham DM;Himmelfarb CD
通讯作者：
Himmelfarb CD
DOI：
10.1177/1740774510373798
发表时间：
2010-08
期刊：
Clinical trials (London, England)
影响因子：
--
作者：
Zook PM;Jordan C;Adams B;Visness CM;Walter M;Pollenz K;Logan J;Tesson E;Smartt E;Chen A;D'Agostino J;Gern JE
通讯作者：
Gern JE