Insect ferritins: Typical or atypical?
Insect ferritins: Typical or atypical?
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DOI：
10.1016/j.bbagen.2010.03.004
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Winzerling JJ
中科院分区：
文献类型：
--
作者：
Pham DQ;Winzerling JJ
昆虫每年传播数百万例疾病，造成数百万美元的农业损失。虫媒疾病的控制对许多发展中国家至关重要，而农业害虫的管理对发达国家来说是一件非常严肃的事情。控制方法应针对昆虫的特异性性状，以避免非目标效应，特别是在哺乳动物中。由于昆虫细胞与脊椎动物的细胞有十亿年的进化差异，它们在许多方面的差异可能对昆虫控制领域有希望-特别是在铁代谢方面，因为目前的研究表明昆虫和哺乳动物系统之间存在显着差异。昆虫的铁代谢与脊椎动物的不同之处在于以下几个方面。昆虫的铁蛋白比哺乳动物的铁蛋白重。与哺乳动物不同，昆虫铁蛋白亚基通常是糖基化的，并与信号肽合成。昆虫铁蛋白的晶体结构是由12个重链和12个轻链亚基组成的四面体对称，而哺乳动物铁蛋白的晶体结构是由24个重链和24个轻链亚基组成的八面体对称。昆虫铁蛋白主要与液泡系统相关，并作为铁转运蛋白-与哺乳动物铁蛋白完全相反，哺乳动物铁蛋白主要存在于细胞质中，并作为铁储存蛋白。本文将讨论这些差异。
Insects transmit millions of cases of disease each year, and cost millions of dollars in agricultural losses. The control of insect-borne diseases is vital for numerous developing countries, and the management of agricultural insect pests is a very serious business for developed countries. Control methods should target insect-specific traits in order to avoid non-target effects, especially in mammals. Since insect cells have had a billion years of evolutionary divergence from those of vertebrates, they differ in many ways that might be promising for the insect control field—especially, in iron metabolism because current studies have indicated that significant differences exist between insect and mammalian systems. Insect iron metabolism differs from that of vertebrates in the following respects. Insect ferritins have a heavier mass than mammalian ferritins. Unlike their mammalian counterparts, the insect ferritin subunits are often glycosylated and are synthesized with a signal peptide. The crystal structure of insect ferritin also shows a tetrahedral symmetry consisting of 12 heavy chain and 12 light chain subunits in contrast to that of mammalian ferritin that exhibits an octahedral symmetry made of 24 heavy chain and 24 light chain subunits. Insect ferritins associate primarily with the vacuolar system and serve as iron transporters—quite the opposite of the mammalian ferritins, which are mainly cytoplasmic and serve as iron storage proteins. This review will discuss these differences.
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DOI：
10.1111/j.1432-1033.1997.00470.x
发表时间：
1997-07-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Charlesworth, A;Georgieva, T;Kafatos, FC
通讯作者：
Kafatos, FC
影响因子：
4.8
作者：
Ferreira, C;Bucchini, D;Beaumont, C
通讯作者：
Beaumont, C
影响因子：
3.8
作者：
Du, JP;Foissac, X;Gatehouse, JA
通讯作者：
Gatehouse, JA
影响因子：
3.9
作者：
ANDREWS, SC;AROSIO, P;YEWDALL, SJ
通讯作者：
YEWDALL, SJ
影响因子：
20.3
作者：
Epsztejn, S;Glickstein, H;Cabantchik, ZI
通讯作者：
Cabantchik, ZI