ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle.
ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle.
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ATP 是人空肠环形平滑肌中快速抑制连接电位的介质。
DOI：
10.1152/ajpgi.1999.276.6.g1373
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Szurszewski,JH
中科院分区：
文献类型：
--
作者：
Xue,L;Farrugia,G;Sarr,MG;Szurszewski,JH
The neurotransmitter(s) that generates the fast component of the inhibitory junction potential (IJP-F) in human jejunal circular smooth muscle is not known. The aim of this study was to determine the role of ATP and purinergic receptors in the generation of the IJP-F in human jejunal circular smooth muscle strips. The P2-receptor antagonist suramin (100 μM) reduced the IJP-F by 28%. Apamin (1 μM) reduced the IJP-F by 25%. Desensitization of muscle strips with the putative P2x-receptor agonist α,β-methylene ATP (α,β-MeATP, 100 μM) decreased the IJP-F by 44%, and desensitization with the putative P2y-receptor agonist adenosine 5′-O-2-thiodiphosphate (ADPβS) completely abolished the IJP-F. Desensitization with the putative P2y-receptor agonist 2-methylthioATP had no effect on the IJP-F. Exogenous ATP evoked a hyperpolarization with a time course that matched the IJP-F. The ATP-evoked hyperpolarization was reduced by apamin and suramin, reduced by desensitization with α,β-MeATP (69% decrease), and abolished by desensitization with ADPβS. These data suggest that the IJP-F in human jejunal circular smooth muscle is mediated in part by ATP through an ADPβS-sensitive P2receptor.
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影响因子：
7.3
作者：
Hideka Suzuki;S. Kokubun
通讯作者：
S. Kokubun
影响因子：
29.4
作者：
Mark E. Stark;Anthony J. Bauer;Michel G. Sarr;J. Szurszewski
通讯作者：
Mark E. Stark;Anthony J. Bauer;Michel G. Sarr;J. Szurszewski
DOI：
10.1113/jphysiol.1991.sp018904
发表时间：
1991-12
期刊：
The Journal of Physiology
影响因子：
--
作者：
M. Stark;A. Bauer;J. Szurszewski
通讯作者：
M. Stark;A. Bauer;J. Szurszewski
ATP 和 PACAP 作为豚鼠结肠环肌中 apamin 敏感 NANC 抑制连接电位介质的可能作用
影响因子：
7.3
作者：
V. Zagorodnyuk;P. Santicioli;C. Maggi;A. Giachetti
通讯作者：
A. Giachetti
神经释放和物质的作用既不通过肾上腺素受体也不通过胆碱受体影响肠肌。
DOI：
--
发表时间：
1973
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
J. Furness;M. Costa
通讯作者：
M. Costa