Impaired Exercise-Induced Blood Volume in Type 2 Diabetes With or Without Peripheral Arterial Disease Measured by Continuous-Wave Near-Infrared Spectroscopy A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
Impaired Exercise-Induced Blood Volume in Type 2 Diabetes With or Without Peripheral Arterial Disease Measured by Continuous-Wave Near-Infrared Spectroscopy A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
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通过连续波近红外光谱测量患有或不患有外周动脉疾病的 2 型糖尿病患者运动引起的血容量受损 本期其他表格显示了许多物质的常规单位和国际系统 (SI) 单位以及换算系数。
作者：
E. Mohler;G. Lech;G. Supple;Hao Wang;B. Chance
糖尿病是外周动脉疾病（PAD）的一个重要危险因素，并与加速动脉粥样硬化和肢体丧失有关。然而，PAD涉及的病理生理学尚不清楚。本研究旨在评价运动对糖尿病和PAD患者血流动力学的影响。研究设计和方法-使用近红外光谱（NIRS）测定糖尿病、PAD或两者兼有患者小腿肌肉的血流动力学反应。患者进行跖屈和步行锻炼方案。近红外光谱法测定，踝臂指数正常的糖尿病患者下肢在运动过程中的骨骼肌毛细血管血容量扩张明显受损。通过NIRS测量的相对脱氧和氧合恢复时间与PAD的存在显著相关。结论：即使没有PAD，糖尿病患者的毛细血管容积扩张也会减少。这可能是由于继发于内皮功能障碍的血管舒张受损所致。需要进一步的研究来确定药物干预是否改善了糖尿病状态下的血容量扩张。
OBJECTIVE—Diabetes is a significant risk factor for peripheral arterial disease (PAD) and is associated with accelerated atherosclerosis and limb loss. However, the pathophysiology involved in PAD is unclear. This study was conducted to evaluate the hemodynamic response to exercise of patients with and without diabetes and PAD. RESEARCH DESIGN AND METHODS—The hemodynamic response in calf muscles of patients with diabetes, PAD, or both was determined using near-infrared spectroscopy (NIRS). Patients performed both a plantar-flexion and treadmill-walking exercise regimen. RESULTS—Skeletal muscle capillary blood volume expansion during exercise, as measured by NIRS, was significantly impaired in the lower extremities of diabetic patients with a normal ankle-brachial index. The relative deoxygenation and oxygenation recovery times measured by NIRS correlates significantly with the presence of PAD. CONCLUSIONS—Patients with diabetes have reduced capillary volume expansion even without PAD. This is likely due to impaired vasodilation secondary to endothelial dysfunction. Further studies are needed to determine whether pharmaceutical intervention improves the blood volume expansion in the diabetic state.
影响因子：
--
作者：
CHANCE, B;DAIT, MT;HAGERMAN, F
通讯作者：
HAGERMAN, F
影响因子：
37.8
作者：
Williams, SB;Goldfine, AB;Creager, MA
通讯作者：
Creager, MA