Cytokine levels in the sera of patients with idiopathic pulmonary fibrosis.
Cytokine levels in the sera of patients with idiopathic pulmonary fibrosis.
复制标题
特发性肺纤维化患者血清中的细胞因子水平。
DOI：
10.1016/j.rmed.2005.06.016
复制
发表时间：
2006
影响因子：
4.3
通讯作者：
Pashalis
中科院分区：
文献类型：
--
作者：
P. Tsoutsou;K. Gourgoulianis;E. Petinaki;A. Germenis;A. Tsoutsou;M. Mpaka;S. Efremidou;Pashalis
原发性肺纤维化（IPF）是一种纤维增生性疾病。本研究旨在比较IPF患者和健康志愿者中参与Th-1和Th-2免疫的细胞因子，如白细胞介素（IL）、IL-2、IL-4、IL-8、IL-10、干扰素-γ（IFN-γ）和IL-12（p40）的血清水平。方法采用酶联免疫吸附试验（ELISA）检测20例IPF患者和40例健康对照者血清IL-2、IL-8、IL-10、IL-12（p40）水平，结果IPF组血清IL-2、IL-8、IL-10、IL-12（p40）水平分别为1.05U/ml、12.55、10.13、44.17pg/ml; 0.05U/ml、6.91、0.75、4.51pg/ml（P<0.05）。IPF组血清IFN-γ水平（0.19pg/ml）低于对照组（0.49pg/ml）。两组间IL-4值无统计学差异：IPF组为8.40 pg/ml，对照组为7.46 pg/ml（P>0.05）。IL-4与FEV1%、FVC%呈正相关（P<0.005），IL-8与FEV1%、FVC %呈负相关（P<0.005）。发现IPF患者血清中IFN-γ降低。
BACKGROUNDIdiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder. Cytokines contribute an important but yet undefined role to its pathogenesis.OBJECTIVESThe present study aims to compare serum levels of cytokines involved in Th-1 and Th-2 immunity, such as interleukins (IL) IL-2, IL-4, IL-8, IL-10, interferon-γ (IFN-γ) and IL-12 (p40) in patients with IPF and healthy volunteers. Twenty patients with IPF and 40 healthy controls (HC) participated.METHODSCytokines were assessed by enzyme-linked immunoabsorbent assay (ELISA).RESULTSMedian values of serum IL-2, IL-8, IL-10, IL-12 (p40) were higher in the IPF than the control group: IPF group: 1.05U/ml, 12.55, 10.13, 44.17pg/ml; control group: 0.05U/ml, 6.91, 0.75, 4.51pg/ml, respectively (P<0.05). IFN-γ serum levels were lower in the IPF (0.19pg/ml) than in the control group (0.49pg/ml). IL-4 values did not differ in a statistically significant way among the groups: 8.40pg/ml in the IPF group, and 7.46pg/ml in the control group (P>0.05). IL-4 positively correlated to fast expiratory volume in 1s (FEV1%) and forced vital capacity (FVC%), while IL-8 negatively correlated to the respective values (P<0.005).CONCLUSIONSIL-2, IL-8, IL-10 and IL-12 (p40) were found to be elevated in the sera of patients with IPF. IFN-γ was found to be decreased in the sera of patients with IPF.
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DOI：
10.1152/ajplung.2001.281.1.l92
发表时间：
2001-07-01
影响因子：
4.9
作者：
Keane, MP;Belperio, JA;Strieter, RM
通讯作者：
Strieter, RM
DOI：
10.1164/ajrccm/145.6.1433
发表时间：
1992-06-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
LYNCH, JP;STANDIFORD, TJ;STRIETER, RM
通讯作者：
STRIETER, RM
DOI：
--
发表时间：
1996-09
期刊：
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
影响因子：
--
作者：
S. L. Kunkel;N. Lukacs;Robert M. Strieter;S. Chensue
通讯作者：
S. L. Kunkel;N. Lukacs;Robert M. Strieter;S. Chensue
影响因子：
1.7
作者：
KUNKEL, SL;STANDIFORD, T;STRIETER, RM
通讯作者：
STRIETER, RM
影响因子：
1.7
作者：
GURUJEYALAKSHMI, G;GIRI, SN
通讯作者：
GIRI, SN