Diagnosis and treatment of pain in small-fiber neuropathy.

Diagnosis and treatment of pain in small-fiber neuropathy.
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DOI:
10.1007/s11916-011-0181-7
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发表时间:
2011-06
影响因子:
3.7
通讯作者:
Gibbons, Christopher H.
Gibbons, Christopher H.
中科院分区:
医学3区
文献类型:
--
作者:
Hovaguimian, Alexandra;Gibbons, Christopher H.

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小纤维神经病表现在各种不同的疾病中,通常会导致灼痛、射击痛、痛觉异常和感觉过敏的症状。小纤维神经病的诊断主要取决于病史和体格检查,但功能神经生理学检查和皮肤活检评估表皮内神经纤维密度可提供诊断确认。小纤维神经病的治疗取决于潜在的病因和相关的神经病理性疼痛的同时治疗。最近的各种指南建议使用抗抑郁药、抗惊厥药、阿片类药物、局部治疗和非药物治疗作为神经病理性疼痛整体管理的一部分。不幸的是,几乎没有专门针对小纤维神经病的疼痛治疗的数据,因为大多数研究在分析中结合了混合性神经病理性疼痛综合征。还需要针对小纤维神经病疼痛的治疗进行其他研究,以指导决策。
Small fiber neuropathy manifests in a variety of different diseases and often results in symptoms of burning pain, shooting pain, allodynia, and hyperesthesia. Diagnosis of small fiber neuropathy is determined primarily by the history and physical exam, but functional neurophysiologic testing and skin biopsy evaluation of intraepidermal nerve fiber density can provide diagnostic confirmation. Management of small fiber neuropathy depends on the underlying etiology with concurrent treatment of associated neuropathic pain. A variety of recent guidelines propose the use of antidepressants, anticonvulsants, opioids, topical therapies, and nonpharmacologic treatments as part of the overall management of neuropathic pain. Unfortunately, little data about the treatment of pain specifically in small fiber neuropathy exist because most studies combine mixed neuropathic pain syndromes in the analysis. Additional studies targeting the treatment of pain in small fiber neuropathy are needed to guide decision making.
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