Co-translational control of protein complex formation: a fundamental pathway of cellular organization?
Co-translational control of protein complex formation: a fundamental pathway of cellular organization?
复制标题
蛋白质复合物形成的共翻译控制：细胞组织的基本途径？
DOI：
10.1042/bst20170451
复制
发表时间：
2018
影响因子：
3.9
通讯作者：
B. Dichtl
中科院分区：
文献类型：
--
作者：
N. K. Williams;B. Dichtl
对整个生命领域大量生物的蛋白质组的分析强调了多蛋白复合物在实现细胞功能方面所发挥的关键作用。虽然多蛋白组装体的出现是普遍存在的，但对决定四级结构形成的途径的理解仍然是个谜。有趣的是，现在已经有了在原核生物和真核生物中共同组装蛋白质复合物的成熟例子，并且有迹象表明这种现象在细胞中广泛存在。在这里，我们回顾复杂的组装，重点是共翻译途径，其中涉及新生链与其他新生或成熟的伙伴蛋白的相互作用，分别。在原核生物中，这样的相互作用通过mRNA的多顺反子排列和功能相关的细胞成分的相关共翻译来促进，以增强其他扩散依赖性过程。然而，除了随机事件之外，共翻译复合物的形成可能对亚基的可用性敏感，并允许对组装过程进行整体调节。我们推测如何共翻译途径可能构成质量控制系统的组成部分，以确保正确和完整的形成数百个异质组件在一个单一的细胞。固有无序结构域的折叠与结合配偶体的共翻译相互作用的偶联可以进一步提高获得正确构象的效率和保真度。共翻译复合物的形成可能构成细胞组织的基本途径，对健康和疾病具有深远的重要性。
Analyses of proteomes from a large number of organisms throughout the domains of life highlight the key role played by multiprotein complexes for the implementation of cellular function. While the occurrence of multiprotein assemblies is ubiquitous, the understanding of pathways that dictate the formation of quaternary structure remains enigmatic. Interestingly, there are now well-established examples of protein complexes that are assembled co-translationally in both prokaryotes and eukaryotes, and indications are that the phenomenon is widespread in cells. Here, we review complex assembly with an emphasis on co-translational pathways, which involve interactions of nascent chains with other nascent or mature partner proteins, respectively. In prokaryotes, such interactions are promoted by the polycistronic arrangement of mRNA and the associated co-translation of functionally related cell constituents in order to enhance otherwise diffusion-dependent processes. Beyond merely stochastic events, however, co-translational complex formation may be sensitive to subunit availability and allow for overall regulation of the assembly process. We speculate how co-translational pathways may constitute integral components of quality control systems to ensure the correct and complete formation of hundreds of heterogeneous assemblies in a single cell. Coupling of folding of intrinsically disordered domains with co-translational interaction of binding partners may furthermore enhance the efficiency and fidelity with which correct conformation is attained. Co-translational complex formation may constitute a fundamental pathway of cellular organization, with profound importance for health and disease.
登录
查看更多内容
影响因子：
56.9
作者：
Brendza, RP;Serbus, LR;Saxton, WM
通讯作者：
Saxton, WM
影响因子：
4
作者：
Dennerlein, Sven;Rehling, Peter
通讯作者：
Rehling, Peter
影响因子：
16
作者：
Wang, Feng;Durfee, Larissa A.;Huibregtse, Jon M.
通讯作者：
Huibregtse, Jon M.
DOI：
10.1073/pnas.93.21.11504
发表时间：
1996-10-15
影响因子：
11.1
作者：
Kriwacki, RW;Hengst, L;Wright, PE
通讯作者：
Wright, PE
影响因子：
16
作者：
Duttler, Stefanie;Pechmann, Sebastian;Frydman, Judith
通讯作者：
Frydman, Judith