The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice.
The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice.
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在小鼠中，碘化物转运蛋白 Slc26a7 对甲状腺功能的影响比 Slc26a4 更强烈。
DOI：
10.1038/s41598-022-15151-4
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发表时间：
2022-07-04
影响因子：
4.6
通讯作者：
Saitoh, Shinji
中科院分区：
文献类型：
--
作者：
Yamaguchi, Naoya;Suzuki, Atsushi;Yoshida, Aya;Tanaka, Tatsushi;Aoyama, Kohei;Oishi, Hisashi;Hara, Yuichiro;Ogi, Tomoo;Amano, Izuki;Kameo, Satomi;Koibuchi, Noriyuki;Shibata, Yasuhiro;Ugawa, Shinya;Mizuno, Haruo;Saitoh, Shinji
SLC26A4是一种已知的碘转运蛋白，定位于甲状腺细胞顶膜。此前，我们报道了SLC26A7也参与了碘的转运，SLC26A7是一个新的先天性甲状腺功能减退的致病基因。然而，其在体内的具体作用仍有待阐明。我们产生了SLC26a7和SLC26A4缺乏的小鼠，以描绘它们在碘转运中的作用的差异和联系。SLC26a7−/−小鼠在正常饮食条件下表现出甲状腺肿大、先天性甲状腺功能减退和轻度生长障碍。SLC26a7−/−小鼠在低碘环境下表现出明显的生长障碍。相比之下，SLC26A4−/−小鼠在相同的低碘环境下没有表现出生长障碍和甲状腺功能减退。双缺陷小鼠表现出比SLc26a7−/−小鼠更严重的生长障碍。序列分析表明，SLC26a7−/−小鼠的差异表达基因(DEG)数显著高于SLC26A4−/−小鼠。这表明SLC26A7在碘转运和维持甲状腺功能方面比SLC26A4更重要。
SLC26A4 is a known iodide transporter, and is localized at the apical membrane of thyrocytes. Previously, we reported that SLC26A7 is also involved in iodide transport and that Slc26a7 is a novel causative gene for congenital hypothyroidism. However, its detailed role in vivo remains to be elucidated. We generated mice that were deficient in Slc26a7 and Slc26a4 to delineate differences and associations in their roles in iodide transport. Slc26a7−/− mice showed goitrous congenital hypothyroidism and mild growth failure on a normal diet. Slc26a7−/− mice with a low iodine environment showed marked growth failure. In contrast, Slc26a4−/− mice showed no growth failure and hypothyroidism in the same low iodine environment. Double-deficient mice showed more severe growth failure than Slc26a7−/− mice. RNA-seq analysis revealed that the number of differentially expressed genes (DEGs) in Slc26a7−/− mice was significantly higher than that in Slc26a4−/− mice. These indicate that SLC26A7 is more strongly involved in iodide transport and the maintenance of thyroid function than SLC26A4.
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影响因子：
4.6
作者：
Ferrandino G;Kaspari RR;Reyna-Neyra A;Boutagy NE;Sinusas AJ;Carrasco N
通讯作者：
Carrasco N
影响因子：
4.8
作者：
Pesce, Liuska;Bizhanova, Aigerim;Kopp, Peter
通讯作者：
Kopp, Peter
影响因子：
5.8
作者：
Zou, Minjing;Alzahrani, Ali S.;Shi, Yufei
通讯作者：
Shi, Yufei
影响因子：
14.9
作者：
Navarro Gonzalez J;Zweig AS;Speir ML;Schmelter D;Rosenbloom KR;Raney BJ;Powell CC;Nassar LR;Maulding ND;Lee CM;Lee BT;Hinrichs AS;Fyfe AC;Fernandes JD;Diekhans M;Clawson H;Casper J;Benet-Pagès A;Barber GP;Haussler D;Kuhn RM;Haeussler M;Kent WJ
通讯作者：
Kent WJ
影响因子：
5.4
作者：
Calebiro, D.;Porazzi, P.;Persani, L.
通讯作者：
Persani, L.