The UCSC Genome Browser database: 2021 update.

The UCSC Genome Browser database: 2021 update.
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DOI:
10.1093/nar/gkaa1070
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发表时间:
2021-01-08
影响因子:
14.9
通讯作者:
Kent WJ
Kent WJ
中科院分区:
生物学2区
文献类型:
--
作者:
Navarro Gonzalez J;Zweig AS;Speir ML;Schmelter D;Rosenbloom KR;Raney BJ;Powell CC;Nassar LR;Maulding ND;Lee CM;Lee BT;Hinrichs AS;Fyfe AC;Fernandes JD;Diekhans M;Clawson H;Casper J;Benet-Pagès A;Barber GP;Haussler D;Kuhn RM;Haeussler M;Kent WJ

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二十多年来,UCSC基因组浏览器数据库(https:genome.ucsc.edu)为研究社区提供了高质量的基因组学数据可视化和基因组注释。随着基因组学领域的发展和更多的数据变得可用,需要新的显示模式来适应新技术。过去一年发布的新功能包括Hi-C热图显示,VCF文件的分阶段家庭三重奏显示,以及各种轨道可视化改进。为了努力保持数据的最新,基因注释的新更新包括GENCODE Genes,NCBI RefSeq Genes和Ensembl Genes。为人类和小鼠基因组添加的新数据跟踪包括候选顺式调控元件的ENCODE登记、来自真核启动子数据库的启动子、以及来自NCBI和EMBL-EBI(马内)的NCBI RefSeq Select和匹配注释。在了解冠状病毒爆发的几周内,UCSC发布了一个基因组浏览器,带有详细的注释轨迹,用于SARS-CoV-2 RNA参考组装。
For more than two decades, the UCSC Genome Browser database (https://genome.ucsc.edu) has provided high-quality genomics data visualization and genome annotations to the research community. As the field of genomics grows and more data become available, new modes of display are required to accommodate new technologies. New features released this past year include a Hi-C heatmap display, a phased family trio display for VCF files, and various track visualization improvements. Striving to keep data up-to-date, new updates to gene annotations include GENCODE Genes, NCBI RefSeq Genes, and Ensembl Genes. New data tracks added for human and mouse genomes include the ENCODE registry of candidate cis-regulatory elements, promoters from the Eukaryotic Promoter Database, and NCBI RefSeq Select and Matched Annotation from NCBI and EMBL-EBI (MANE). Within weeks of learning about the outbreak of coronavirus, UCSC released a genome browser, with detailed annotation tracks, for the SARS-CoV-2 RNA reference assembly.
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