Moody kids years later: Long-term outcomes of youth from the Omega-3 and therapy (OATS) studies.
Moody kids years later: Long-term outcomes of youth from the Omega-3 and therapy (OATS) studies.
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多年后，喜怒无常的孩子：欧米茄3和治疗（燕麦）研究的青年长期成果。
DOI：
10.1016/j.jad.2020.11.115
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发表时间：
2021-02-15
影响因子：
6.6
通讯作者：
Arnold LE
中科院分区：
文献类型：
--
作者：
Fristad MA;Roley-Roberts ME;Black SR;Arnold LE
这项自然主义的随访研究检查了参与omega-3脂肪酸（Ω3）、个体家庭心理教育心理治疗（IF-PEP）及其组合的随机临床试验（RCT）2-5年后抑郁症（n= 2 - 5）或亚综合征双相情感障碍（n=13）青年的结局。40%（38/95）的RCT家庭完成了随访评估。复发率和转化为双相情感障碍与已发表的文献一致。原始治疗分配不影响当前功能。总体而言，参与者的情绪严重程度，执行功能和整体功能继续优于RCT基线。自随机对照试验结束以来，抑郁症状显着增加。躁狂症状严重程度、执行功能和整体功能与RCT结束时相当。大多数家长和青少年报告改善了青少年的情绪调节技能和家庭沟通。他们认为参与研究是有益的，增加对情绪障碍的理解是最主要的原因。一半的年轻人开始或继续Ω3，58%的人开始或继续心理治疗后RCT，这表明一定程度的消费者满意度;这些年轻人的抑郁严重程度低于其他参与者。只有40%的人返回到这个自然的后续行动;他们不太可能有一个非洲裔美国人的父母，收入较高，年轻人在RCT结束时比那些没有返回的症状。尽管从RCT结束到随访时抑郁症状严重程度增加，但相对于RCT基线的改善仍在继续。2-5年后，青年和家庭功能持续得到有意义的改善。对于这些脆弱人群，仍然需要采取干预措施，防止复发或转为BPSD。
This naturalistic follow-up study examines outcomes for youth with depression (n=25) or subsyndromal bipolar disorder (n=13) 2–5 years after participation in randomized clinical trials (RCTs) of omega-3 fatty acids (Ω3), individual family psychoeducational psychotherapy (IF-PEP), and their combination. Forty percent (38/95) of RCT families completed a follow-up assessment. Relapse rates and conversion to bipolar disorder were consistent with published literature. Original treatment assignment did not impact current functioning. Overall, participants’ mood severity, executive functioning, and global functioning continued to be better than at RCT baseline. Depressive symptoms increased significantly from end of RCT. Manic symptom severity, executive functioning, and global functioning remained comparable to end of RCT. The majority of parents and youth reported improved youth emotion regulation skills and family communication. They considered study participation beneficial, with increased understanding of mood disorders being the top reason. Half of youth commenced or continued Ω3 and 58% commenced or continued psychotherapy post-RCT, suggesting some degree of consumer satisfaction; these youth had lower depression severity than other participants. Only 40% returned to this naturalistic follow-up; they were less likely to have an African-American parent, were of higher income, and youth were more symptomatic at end of RCT than those who did not return. Improvement from RCT baseline continued although depressive symptom severity increased from end of RCT to follow-up. Meaningful improvements in youth and family functioning persisted 2–5 years later. Interventions that prevent relapse or conversion to BPSD are still needed for these vulnerable populations.
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影响因子：
5.4
作者：
Goldstein BI;Birmaher B;Carlson GA;DelBello MP;Findling RL;Fristad M;Kowatch RA;Miklowitz DJ;Nery FG;Perez-Algorta G;Van Meter A;Zeni CP;Correll CU;Kim HW;Wozniak J;Chang KD;Hillegers M;Youngstrom EA
通讯作者：
Youngstrom EA
影响因子：
120.7
作者：
Asarnow, JR;Jaycox, LH;Wells, KB
通讯作者：
Wells, KB
DOI：
10.3109/10401239509149039
发表时间：
1995-09-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Fristad, M A;Weller, R A;Weller, E B
通讯作者：
Weller, E B
影响因子：
1.9
作者：
Fristad, Mary A.;Young, Andrea S.;Arnold, L. Eugene
通讯作者：
Arnold, L. Eugene
影响因子：
5.3
作者：
Fristad, Mary A.
通讯作者：
Fristad, Mary A.