Analysis of morphological parameters to differentiate rupture status in anterior communicating artery aneurysms.
Analysis of morphological parameters to differentiate rupture status in anterior communicating artery aneurysms.
复制标题
分析形态学参数以区分前交通动脉瘤中的破裂状态。
DOI：
10.1371/journal.pone.0079635
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Du R
中科院分区：
文献类型：
--
作者：
Lin N;Ho A;Charoenvimolphan N;Frerichs KU;Day AL;Du R
与大小相反，颅内动脉瘤的形态特征与破裂的关联尚未系统地建立。我们对与前交通动脉瘤破裂相关的形态变量进行了分析，以确定特定部位的风险变量。 2005 年至 2010 年间，同一机构治疗了 124 例前交通动脉瘤，并对 79 例患者（42 例破裂，37 例未破裂）的 CT 血管造影 (CTA) 或旋转血管造影进行了分析。使用 3D Slicer© 评估血管成像，生成动脉瘤和周围脉管系统的模型。使用单变量和多变量分析检查形态学参数，包括动脉瘤体积、纵横比、尺寸比、分叉距离、动脉瘤角度、血管角、血流角和亲子角。多变量逻辑回归显示，调整年龄、性别、吸烟史和其他临床危险因素后，尺寸比、血流角和亲女角与动脉瘤破裂相关。因此，简单的形态学参数，如尺寸比、血流角和母子角可能有助于评估前交通动脉瘤的破裂风险。
In contrast to size, the association of morphological characteristics of intracranial aneurysms with rupture has not been established in a systematic manner. We present an analysis of the morphological variables that are associated with rupture in anterior communicating artery aneurysms to determine site-specific risk variables. One hundred and twenty-four anterior communicating artery aneurysms were treated in a single institution from 2005 to 2010, and CT angiograms (CTAs) or rotational angiography from 79 patients (42 ruptured, 37 unruptured) were analyzed. Vascular imaging was evaluated with 3D Slicer© to generate models of the aneurysms and surrounding vasculature. Morphological parameters were examined using univariate and multivariate analysis and included aneurysm volume, aspect ratio, size ratio, distance to bifurcation, aneurysm angle, vessel angle, flow angle, and parent-daughter angle. Multivariate logistic regression revealed that size ratio, flow angle, and parent-daughter angle were associated with aneurysm rupture after adjustment for age, sex, smoking history, and other clinical risk factors. Simple morphological parameters such as size ratio, flow angle, and parent-daughter angle may thus aid in the evaluation of rupture risk of anterior communicating artery aneurysms.
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