A Calcium-Deficient Diet in Dams during Gestation Increases Insulin Resistance in Male Offspring.
A Calcium-Deficient Diet in Dams during Gestation Increases Insulin Resistance in Male Offspring.
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妊娠期间大坝中缺乏钙的饮食会增加男性后代的胰岛素抵抗。
DOI：
10.3390/nu10111745
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发表时间：
2018-11-13
期刊：
影响因子：
5.9
通讯作者：
Kaneko K
中科院分区：
文献类型：
--
作者：
Takaya J;Yamanouchi S;Kino J;Tanabe Y;Kaneko K
Calcium (Ca) plays an important role in the pathogenesis of insulin resistance syndrome. Osteocalcin (OC), a bone formation biomarker, acts directly on β-cells and increases insulin secretion. We determined the effects of Ca deficiency during pregnancy and/or lactation on insulin resistance in offspring. Female Wistar rats consumed either a Ca-deficient or control diet ad libitum from three weeks preconception to 21 days postparturition. Pups were allowed to nurse their original mothers until weaning. The offspring were fed a control diet beginning at weaning and were killed on day 180. Serum carboxylated OC (Gla-OC) and undercarboxylated OC (Glu-OC), insulin and adipokines in offspring were measured. In males, mean levels of insulin, glucose, and HOMA-IR were higher in the Ca-deficient group than in the control group. In addition, ionized Ca (iCa) was inversely associated with serum Glu-OC and adiponectin in males. In females, mean levels of Glu-OC and Gla-OC in the Ca-deficient group were higher than in the control group. In all offspring, serum leptin levels were correlated with serum insulin levels, and inversely correlated with iCa. In conclusion, maternal Ca restriction during pregnancy and/or lactation influences postnatal offspring Ca metabolism and insulin resistance in a sex-specific manner.
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影响因子：
6.9
作者：
Kautzky-Willer, Alexandra;Brazzale, Alessandra R.;Pacini, Giovanni
通讯作者：
Pacini, Giovanni
影响因子：
4.1
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Sugimoto, Toshitsugu
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4.1
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通讯作者：
Koranyi, Laszlo
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64.5
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Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
7.7
作者：
Hermans, MP;Levy, JC;Turner, RC
通讯作者：
Turner, RC