Rit subfamily small GTPases: regulators in neuronal differentiation and survival.
Rit subfamily small GTPases: regulators in neuronal differentiation and survival.
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DOI：
10.1016/j.cellsig.2013.06.002
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发表时间：
2013-10
影响因子：
4.8
通讯作者：
Andres DA
中科院分区：
文献类型：
--
作者：
Shi GX;Cai W;Andres DA
Ras family small GTPases serve as binary molecular switches to regulate a broad array of cellular signaling cascades, playing essential roles in a vast range of normal physiological processes, with dysregulation of numerous Ras-superfamily G-protein-dependent regulatory cascades underlying the development of human disease. However, the physiological function for many “orphan” Ras-related GTPases remain poorly characterized, including members of the Rit subfamily GTPases. Rit is the founding member of a novel branch of the Ras subfamily, sharing close homology with the neuronally expressed Rin and Drosophila Ric GTPases. Here, we highlight recent studies using transgenic and knockout animal models which have begun to elucidate the physiological roles for the Rit subfamily, including emerging roles in the regulation of neuronal morphology and cellular survival signaling, and discuss new genetic data implicating Rit and Rin signaling in disorders such as cancer, Parkinson’s disease, autism, and schizophrenia.
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影响因子：
25
作者：
Holton, KL;Loder, MK;Melikian, HE
通讯作者：
Melikian, HE
DOI：
10.1038/nrm3255
发表时间：
2011-12-22
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.5
作者：
Harrison, SMW;Rudolph, JL;Harrison, DA
通讯作者：
Harrison, DA
RIT GTPase调节p38 MAPK依赖性神经元存活途径。
影响因子：
2.5
作者：
Cai W;Rudolph JL;Sengoku T;Andres DA
通讯作者：
Andres DA
影响因子：
13.9
作者：
Barnes AP;Polleux F
通讯作者：
Polleux F