Time course of loss of residual radiation damage in murine skin assessed by retreatment.
Time course of loss of residual radiation damage in murine skin assessed by retreatment.
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通过再治疗评估小鼠皮肤残余辐射损伤消失的时间过程。
DOI：
10.1080/09553008914550301
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发表时间：
1989
影响因子：
2.6
通讯作者：
Travis,EL
中科院分区：
文献类型：
--
作者：
Terry,NH;Tucker,SL;Travis,EL
在一系列第一次剂量后，通过10天至6个月的再次治疗，评估了小鼠足部皮肤中残留的辐射损伤量。以急性皮肤反应为终点。首先用单次剂量(15-37.5Gy)照射小鼠的后脚，照射范围从零到接近全效应。一组未接受过治疗的年龄匹配的对照组小鼠，用全范围的单次剂量进行足部后退。没有观察到与年龄相关的辐射敏感性变化。建立了每一启动剂量的所有再治疗次数的剂量-反应曲线，并计算了峰值皮肤反应和平均皮肤反应的等效剂量。如果在重新治疗之前允许2-6个月的时间，皮肤可以重新照射，就像以前没有治疗过一样。然而，如果在重新治疗前只允许一个月的时间，那么在所有第一次注射之后，损害就会被“记住”。第一次37.5Gy后“记住”的损伤剂量为11Gy.较低的第一次剂量后损伤较小。
The amount of radiation damage remaining in mouse foot skin has been assessed by retreatment from 10 days to 6 months after a range of first doses. The acute skin reaction was used as the endpoint. Mice hind feet were first irradiated with a range of single doses (15–37·5 Gy) covering zero to near full effect. Feet were retreated with a full range of single doses together with groups of non-previously treated age-matched control mice. No age-related changes in radiation sensitivity were observed. Dose–response curves were constructed for all retreatment times for each priming dose, and isoeffect doses were calculated for both peak and average skin reactions. If 2–6 months were allowed to elapse before retreatment, the skin could be reirradiated as if it were previously untreated. However, if only 1 month was allowed to pass before retreatment, damage was ‘remembered’ after all first doses. The amount of damage ‘remembered’ in terms of dose was 11 Gy after a first dose of 37·5 Gy, and was less after the lower first doses.
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[一些生理条件对小鼠皮肤放射敏感性的影响。
DOI：
--
发表时间：
1979
期刊：
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
影响因子：
--
作者：
K. Masuda
通讯作者：
K. Masuda
先前治疗对小鼠足部对辐射和热疗反应的影响。
影响因子：
5.7
作者：
J. Wondergem;J. Haveman
通讯作者：
J. Haveman
重度照射的人体皮肤对再次照射的耐受性。
影响因子：
2.6
作者：
R. Hunter;J. Stewart
通讯作者：
J. Stewart
先前受辐射皮肤的辐射损伤的热增强。
影响因子：
2.6
作者：
M. Law;R. Ahier;S. Somaia
通讯作者：
S. Somaia
通过肺炎评估小鼠肺部的残留辐射损伤。
DOI：
10.1016/0360-3016(88)90015-6
发表时间：
1988
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Terry,NH;Tucker,SL;Travis,EL
通讯作者：
Travis,EL