Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors.
Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors.
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DOI：
10.1016/j.nucmedbio.2013.12.002
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发表时间：
2014-03
影响因子：
3.1
通讯作者：
Ghandehari H
中科院分区：
文献类型：
--
作者：
Buckway B;Frazier N;Gormley AJ;Ray A;Ghandehari H
使用放射性核素90 Y标记的N-（2-羟丙基）甲基丙烯酰胺（HPMA）共聚物治疗前列腺癌可以通过局部肿瘤热疗来增强。研制了一种111 In标记HPMA共聚物单光子发射计算机断层显像（SPECT）系统，用于观察高温引起的生物分布变化。使用90 Y HPMA共聚物与热疗在携带前列腺肿瘤的小鼠中进行功效研究。通过可逆加成-断裂转移（RAFT）共聚反应合成了含有1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸（DOTA）的HPMA共聚物，并随后用111 In或90 Y进行标记，用于成像或功效研究。在体外用小鼠血清表征放射性标记的稳定性。在携带DU 145前列腺肿瘤的小鼠中进行成像和功效研究。使用单光子发射计算机断层扫描（SPECT）进行成像。局部轻度肿瘤热疗是通过使用金纳米棒的等离子体光热疗法实现的。HPMA共聚物DOTA共轭物表现出有效的标记和稳定性的两种放射性核素。成像分析显示，在高温治疗的前列腺肿瘤内，放射性标记的共聚物显著增加，在非靶组织中没有显著蓄积。在用90 Y HPMA共聚物缀合物热疗处理的肿瘤中观察到肿瘤生长的最大减少。组织学分析证实了治疗的有效性和安全性。用成像和治疗放射性同位素放射性标记的HPMA共聚物-DOTA缀合物，当与热疗组合时，可以用作有效治疗前列腺肿瘤的图像引导方法。
The treatment of prostate cancer using a radiotherapeutic 90Y labeled N-(2-hydroxypropyl)methacrylamide (HPMA)copolymer can be enhanced with localized tumor hyperthermia. An 111In labeled HPMA copolymer system for single photon emission computerized tomography (SPECT) was developed to observe the biodistribution changes associated with hyperthermia. Efficacy studies were conducted in prostate tumor bearing mice using the 90Y HPMA copolymer with hyperthermia. HPMA copolymers containing 1, 4, 7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were synthesized by reversible addition-fragmentation transfer (RAFT) copolymerization and subsequently labeled with either 111In for imaging or 90Y for efficacy studies. Radiolabel stability was characterized in vitro with mouse serum. Imaging and efficacy studies were conducted in DU145 prostate tumor bearing mice. Imaging was performed using single photon emission computerized tomography (SPECT). Localized mild tumor hyperthermia was achieved by plasmonic photothermal therapy using gold nanorods. HPMA copolymer-DOTA conjugates demonstrated efficient labeling and stability for both radionuclides. Imaging analysis showed a marked increase of radiolabeled copolymer within the hyperthermia treated prostate tumors, with no significant accumulation in non-targeted tissues. The greatest reduction in tumor growth was observed in the hyperthermia treated tumors with 90Y HPMA copolymer conjugates. Histological analysis confirmed treatment efficacy and safety. HPMA copolymer-DOTA conjugates radiolabeled with both the imaging and treatment radioisotopes, when combined with hyperthermia can serve as an image guided approach for efficacious treatment of prostate tumors.
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影响因子：
17.4
作者：
Gormley AJ;Larson N;Sadekar S;Robinson R;Ray A;Ghandehari H
通讯作者：
Ghandehari H
DOI：
10.1002/apmc.1978.050700110
发表时间：
1978-01-01
期刊：
ANGEWANDTE MAKROMOLEKULARE CHEMIE
影响因子：
--
作者：
STROHALM, J;KOPECEK, J
通讯作者：
KOPECEK, J
影响因子：
3.1
作者：
Mitra, Amitava;Nan, Anjan;Ghandehari, Hamidreza
通讯作者：
Ghandehari, Hamidreza
影响因子：
16.1
作者：
Kopecek, Jindrich
通讯作者：
Kopecek, Jindrich
DOI：
10.1016/j.jconrel.2013.04.006
发表时间：
2013-08-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Larson N;Gormley A;Frazier N;Ghandehari H
通讯作者：
Ghandehari H