Dynamic FDG-PET demonstration of functional brain abnormalities.

Dynamic FDG-PET demonstration of functional brain abnormalities.
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DOI:
10.1002/acn3.51546
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发表时间:
2022-09
影响因子:
5.3
通讯作者:
Kundu, Bijoy
Kundu, Bijoy
中科院分区:
医学2区
文献类型:
--
作者:
Quigg, Mark;Kundu, Bijoy

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使用氟-18氟脱氧葡萄糖(18F-FDG-PET)的正电子发射断层扫描已被用于绘制脑葡萄糖代谢模式,以评估正常脑功能或证明脑疾病中的代谢异常。传统的PET图模式的绝对示踪剂摄取,但已证明的缺点,如脑肿瘤或局灶性癫痫的能力,从病理组织正常解决的疾病。在这篇综述中,我们描述了一种替代的代谢映射过程,动态PET。这项新技术量化了示踪剂摄取和衰减的动态,目的是改善靶器官中所需代谢活性的功能映射。我们讨论了脑肿瘤治疗和癫痫手术的初步试点研究的技术实施和结果。
Positron emission tomography with fluorine‐18 fluorodeoxyglucose (18F‐FDG‐PET) has been used over 3 decades to map patterns of brain glucose metabolism to evaluate normal brain function or demonstrate abnormalities of metabolism in brain disorders. Traditional PET maps patterns of absolute tracer uptake but has demonstrated shortcomings in disorders such as brain neoplasm or focal epilepsy in the ability to resolve normally from pathological tissue. In this review, we describe an alternative process of metabolic mapping, dynamic PET. This new technology quantifies the dynamics of tracer uptake and decays with the goal of improving the functional mapping of the desired metabolic activity in the target organ. We discuss technical implementation and findings of initial pilot studies in brain tumor treatment and epilepsy surgery.
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期刊: NEURO-ONCOLOGY
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