Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury.
Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury.
复制标题
低剂量紫杉醇促进脊髓损伤后神经元轴突延伸和功能恢复
DOI：
10.1155/2023/5604103
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发表时间：
2023
影响因子：
4.6
通讯作者：
Sun, Dejun
中科院分区：
文献类型：
--
作者：
Liu, Baoguo;Liu, Sumei;Sun, Dejun
轴突再生一直是脊髓损伤临床治疗领域的研究热点。神经元轴突的生长和延伸是一个由细胞骨架介导的动态生物学过程，微管在轴突生长中起着重要作用。微管的适度稳定促进轴突生长，消除各种阻碍轴突再生的细胞内和细胞外机制。脊髓损伤后，受损的轴突迅速形成生长锥，其中微管蛋白的稳定性下降，损害轴突再生。紫杉醇是一种常用的广谱抗肿瘤药物，具有良好的临床安全性。重要的是，紫杉醇可以通过增强和稳定微管组装来促进轴突延伸。在我们的研究中，我们系统地研究了紫杉醇治疗后神经干细胞（NSCs）的体外分化和损伤大鼠体内功能恢复。低剂量紫杉醇可促进NSCs向神经元分化，显著延长轴突。在体内，紫杉醇促进了损伤区域β iii -微管蛋白的表达和脊髓损伤后运动功能的恢复。小剂量紫杉醇是一种很有前景的促进脊髓损伤后轴突再生的临床药物。
Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and microtubule plays an important role in axonal growth. Moderate stabilization of microtubule promotes axonal growth and eliminates various intra- and extracellular mechanisms that impede axonal regeneration. After SCI, the damaged axons rapidly form a growth cone, wherein the stability of tubulin decreases, impairing axonal regeneration. Taxol with proven clinical safety is commonly used as a broad-spectrum antitumor drug. Importantly, Taxol can promote axonal extension by enhancing and stabilizing the microtubule assembly. In our study, we systematically investigated the differentiation of neural stem cells (NSCs) in vitro and functional recovery in injured rats in vivo following Taxol treatment. Low-dose Taxol promoted differentiation of NSCs to neurons and significantly extended the axons in vitro. In vivo, Taxol promoted the expression of βIII-tubulin in the injured areas and motor function recovery after SCI. Low-dose Taxol is a promising clinical agent to promote axonal regeneration after SCI.
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影响因子：
5.3
作者：
Fournier, AE;Takizawa, BT;Strittmatter, SM
通讯作者：
Strittmatter, SM
影响因子：
4.2
作者：
Soldati, Chiara;Caramanica, Pasquale;Cacci, Emanuele
通讯作者：
Cacci, Emanuele
DOI：
10.1196/annals.1377.013
发表时间：
2006-01-01
期刊：
INTEGRATED MOLECULAR MEDICINE FOR NEURONAL AND NEOPLASTIC DISORDERS
影响因子：
--
作者：
Yoshimura, Takeshi;Arimura, Nariko;Kaibuchi, Kozo
通讯作者：
Kaibuchi, Kozo
影响因子：
64.8
作者：
BENTLEY, D;TOROIANRAYMOND, A
通讯作者：
TOROIANRAYMOND, A
影响因子：
64.8
作者：
BAMBURG, JR;BRAY, D;CHAPMAN, K
通讯作者：
CHAPMAN, K