Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1.

Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1.
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DOI:
10.3390/ijms22073360
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发表时间:
2021-03-25
影响因子:
5.6
通讯作者:
Lyall V
Lyall V
中科院分区:
生物学2区
文献类型:
--
作者:
Rhyu MR;Kim Y;Lyall V

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除了味觉和嗅觉之外,化学感觉,即香料和草药引起的刺激、辛辣、清凉、温暖或燃烧的感觉,在食物消耗中起着核心作用。许多植物源性分子通过打开瞬时受体电位锚蛋白 1 (TRPA1) 和瞬时受体电位香草酸 1 (TRPV1) 通道来展示其化学感觉特性。 TRPA1 和 TRPV1 是结构相关的热敏阳离子通道,通常在感觉神经末梢中共表达。 TRPA1 和 TRPV1 还可以通过三叉神经元释放 P 物质和降钙素基因相关肽 (CGRP) 以及随后对 III 型味觉受体细胞中表达的 CGRP 受体的影响来间接影响一些但不是全部的主要味觉品质。在这里,我们将回顾一些 TRPA1 和 TRPV1 化学感觉激动剂的作用及其对苦味、酸味和咸味品质的影响。
In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expressed in sensory nerve endings. TRPA1 and TRPV1 can also indirectly influence some, but not all, primary taste qualities via the release of substance P and calcitonin gene-related peptide (CGRP) from trigeminal neurons and their subsequent effects on CGRP receptor expressed in Type III taste receptor cells. Here, we will review the effect of some chemesthetic agonists of TRPA1 and TRPV1 and their influence on bitter, sour, and salt taste qualities.
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