Hippocampal neurons code individual episodic memories in humans

Hippocampal neurons code individual episodic memories in humans
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海马神经元编码人类的个体情景记忆

DOI:
10.1101/2021.06.28.450149
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发表时间:
2021
期刊:
--
影响因子:
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通讯作者:
Kolibius L
Kolibius L
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--
文献类型:
--
作者:
Kolibius L

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海马体是情景记忆处理的重要中枢。然而,人类海马单个神经元如何编码多元素关联仍然是未知的。特别是,它是争论是否每个海马神经元代表一个不变的元素内的情节或单个神经元是否绑定在一起的离散情节记忆的所有元素。在这里,我们为后一种假设提供了证据。使用单神经元记录从总共30名参与者,我们表明,个别神经元,我们术语的情节特异性神经元,编码离散的情节记忆使用率代码或时间发射代码。这些神经元仅在海马体中观察到。重要的是,这些情节特异性神经元并不反映情节中特定元素(即概念或时间)的编码。相反,它们为组成情节的不同元素的结合编码。
The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the episode (that is, concept or time). Instead, they code for the conjunction of the different elements that make up the episode.
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DOI: --
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期刊: International Conference on Learning Representations
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