Lymphocytes expressing type 3 complement receptors proliferate in response to interleukin 2 and are the precursors of lymphokine-activated killer cells.
Lymphocytes expressing type 3 complement receptors proliferate in response to interleukin 2 and are the precursors of lymphokine-activated killer cells.
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表达 3 型补体受体的淋巴细胞响应白细胞介素 2 进行增殖，并且是淋巴因子激活的杀伤细胞的前体。
DOI：
10.1172/jci113442
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Horwitz,DA
中科院分区：
文献类型：
--
作者：
Gray,JD;Horwitz,DA
In the absence of antigenic or mitogenic stimulation, certain peripheral blood lymphocytes exhibit proliferative and lymphokine-activated killer (LAK) cell activities when cultured with recombinant IL-2. Both activities were found to be an exclusive property of lymphocytes expressing type 3 complement receptors (CR3) identified by anti-CD11 monoclonal antibodies. CD11+ lymphocytes were then fractionated into three subsets by two-color flow cytometry. These included CD16+ cells, which display distinctive Fc receptors for IgG (CD16). Using anti-CD5, the CD11+ CD16- lymphocytes were separated into non-T cell and T cell subsets. The two non-T cell subsets (CD11+ CD16+ and CD11+ CD16- CD5-), but not the T cell subset (CD11+ CD16- CD5+), could proliferate in response to IL-2. Both CD11+ non-T cell subsets, but not the CD11+ T cell subset, had the capacity to mediate natural killer cell activity. However, all three CD11+ lymphocyte subsets were capable of generating LAK activity. These findings are consistent with the concept that two signals are required to stimulate T cells to proliferate. However, at least a small subset of blood T cells can be activated by IL-2 to become LAK cells.
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重组白细胞介素 2 对静息人 T 淋巴细胞的影响。
DOI：
--
发表时间：
1986
期刊：
Journal of Biological Response Modifiers
影响因子：
--
作者：
S. Hammer;J. Gillis
通讯作者：
J. Gillis
人淋巴因子激活的杀伤细胞前体的功能研究。
影响因子：
4.3
作者：
Gray,JD;Shau,HY;Golub,SH
通讯作者：
Golub,SH
影响因子：
4.4
作者：
B. Perussia;G. Trinchieri;A. Jackson;N. Warner;J. Faust;H. Rumpold;D. Kraft;L. Lanier
通讯作者：
B. Perussia;G. Trinchieri;A. Jackson;N. Warner;J. Faust;H. Rumpold;D. Kraft;L. Lanier
影响因子：
--
作者：
Kendall A. Smith;F. Ruscetti
通讯作者：
Kendall A. Smith;F. Ruscetti
DOI：
10.1073/pnas.83.24.9694
发表时间：
1986-12-01
影响因子：
11.1
作者：
TSUDO, M;KOZAK, RW;WALDMANN, TA
通讯作者：
WALDMANN, TA