In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia.
In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia.
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DOI：
10.1038/jp.2017.49
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Laughon MM
中科院分区：
文献类型：
--
作者：
Jackson W;Hornik CP;Messina JA;Guglielmo K;Watwe A;Delancy G;Valdez A;MacArthur T;Peter-Wohl S;Smith PB;Tolia VN;Laughon MM
目的探讨诊断为严重支气管肺发育不良的早产儿的住院结局。回顾性队列研究包括1997-2015年348个儿科医疗集团新生儿重症监护病房出院的严重支气管肺发育不良早产儿。10,752名婴儿患有严重支气管肺发育不良，549/10,752例（5%）在出院前死亡。与幸存者相比，死亡的婴儿更有可能是男性，胎龄较小，接受过更多的医疗干预，并且在月经后36周被诊断为手术坏死性小肠结肠炎，培养证实的败血症和肺动脉高压的频率更高。大约70%患有严重支气管肺发育不良的婴儿在经后44周出院，86%在经后48周出院。大多数诊断为严重支气管肺发育不良的婴儿在经后44周出院回家。这些结果可以告知与家庭讨论诊断为严重支气管肺发育不良的婴儿的预期住院过程。
To characterize in-hospital outcomes of premature infants diagnosed with severe bronchopulmonary dysplasia. Retrospective cohort study including premature infants with severe bronchopulmonary dysplasia discharged from 348 Pediatrix Medical Group neonatal intensive care units from 1997–2015. There were 10,752 infants with severe bronchopulmonary dysplasia, and 549/10,752 (5%) died prior to discharge. Infants who died were more likely to be male, small for gestational age, have received more medical interventions, and more frequently diagnosed with surgical necrotizing enterocolitis, culture-proven sepsis, and pulmonary hypertension following 36 weeks postmenstrual age compared to survivors. Approximately 70% of infants with severe bronchopulmonary dysplasia were discharged by 44 weeks postmenstrual age, and 86% were discharged by 48 weeks postmenstrual age. A majority of infants diagnosed with severe bronchopulmonary dysplasia were discharged home by 44 weeks postmenstrual age. These results may inform discussions with families regarding the expected hospital course of infants diagnosed with severe bronchopulmonary dysplasia.
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