Microglia: key elements in neural development, plasticity, and pathology.
Microglia: key elements in neural development, plasticity, and pathology.
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DOI：
10.1007/s11481-013-9434-z
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发表时间：
2013-06
影响因子：
6.2
通讯作者：
Dailey, Michael E.
中科院分区：
文献类型：
--
作者：
Eyo, Ukpong B.;Dailey, Michael E.
在卡哈尔发现神经系统的“第三个元素”后的世纪，关于其主要组成部分之一小胶质细胞的身份和功能的许多问题已经得到澄清。在这里，我们回顾了小胶质细胞学家的最新发现，强调了成像研究的结果，这些研究有助于提供小胶质细胞行为和功能的新观点。在完整的成年啮齿类动物中枢神经系统的体内成像已经彻底改变了我们对原位小胶质细胞行为的理解，并提出了关于它们在未受伤的成年大脑中的功能的猜测。在离体哺乳动物组织制备和完整的模式生物，包括斑马鱼的成像研究提供了在大脑发育过程中的小胶质细胞的行为的见解。这些数据表明，小胶质细胞在突触重塑，发育性凋亡，吞噬清除和血管生成中发挥重要作用。由于小胶质细胞也有助于病理学，包括神经发育和神经行为障碍，缺血性损伤和神经性疼痛，有希望的新结果提高了利用小胶质细胞治疗作用的可能性。最后，最近令人兴奋的工作正在解决有关小胶质细胞-神经元通信性质的未回答的问题。虽然现在很明显，小胶质细胞在神经发育，行为和病理学中发挥着不同的作用，但未来使用神经成像技术的研究对于更充分地利用这些有趣的细胞靶点用于各种疾病的有效治疗干预至关重要。
A century after Cajal identified a “third element” of the nervous system, many issues have been clarified about the identity and function of one of its major components, the microglia. Here, we review recent findings by microgliologists, highlighting results from imaging studies that are helping provide new views of microglial behavior and function. In vivo imaging in the intact adult rodent CNS has revolutionized our understanding of microglial behaviors in situ and has raised speculation about their function in the uninjured adult brain. Imaging studies in ex vivo mammalian tissue preparations and in intact model organisms including zebrafish are providing insights into microglial behaviors during brain development. These data suggest that microglia play important developmental roles in synapse remodeling, developmental apoptosis, phagocytic clearance, and angiogenesis. Because microglia also contribute to pathology, including neurodevelopmental and neurobehavioral disorders, ischemic injury, and neuropathic pain, promising new results raise the possibility of leveraging microglia for therapeutic roles. Finally, exciting recent work is addressing unanswered questions regarding the nature of microglial-neuronal communication. While it is now apparent that microglia play diverse roles in neural development, behavior, and pathology, future research using neuroimaging techniques will be essential to more fully exploit these intriguing cellular targets for effective therapeutic intervention applied to a variety of conditions.
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影响因子：
5.3
作者：
Carbonell, WS;Murase, SI;Mandell, JW
通讯作者：
Mandell, JW
影响因子：
25
作者：
Davalos, D;Grutzendler, J;Gan, WB
通讯作者：
Gan, WB
影响因子：
3.3
作者：
Chen T;Koga K;Li XY;Zhuo M
通讯作者：
Zhuo M
影响因子：
1.9
作者：
ASHWELL, KWS;HOLLANDER, H;STONE, J
通讯作者：
STONE, J
DOI：
10.1073/pnas.0607423103
发表时间：
2006-10-24
影响因子：
11.1
作者：
Beers, David R.;Henkel, Jenny S.;Appel, Stanley H.
通讯作者：
Appel, Stanley H.