Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury.
Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury.
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白藜芦醇通过激活坐骨神经挤压损伤大鼠模型中 p300 乙酰转移酶介导的 VEGF 信号传导促进神经再生
DOI：
10.3389/fnins.2018.00341
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发表时间：
2018
影响因子：
4.3
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Ding Z;Cao J;Shen Y;Zou Y;Yang X;Zhou W;Guo Q;Huang C
周围神经损伤通常与运动功能的不完全恢复有关。损伤后神经再生速度缓慢可能是造成这一现象的原因。尽管白藜芦醇对神经系统的许多益处已被证明，但尚不清楚白藜芦醇是否可以促进周围神经损伤后的快速神经再生和运动修复。这项研究表明，每天系统性白藜芦醇治疗可在 10 天内缓解坐骨神经挤压损伤引起的运动缺陷。白藜芦醇增加了受伤神经远端部分的轴突数量，表明神经再生能力增强。在受影响的腹侧脊髓中，白藜芦醇增强了几种血管内皮生长因子家族蛋白 (VEGF) 的表达，并通过 Akt 信号传导增加了 p300 的磷酸化，表明 p300 乙酰转移酶被激活。 p300 乙酰转移酶失活可逆转白藜芦醇诱导的 VEGF 表达和坐骨神经挤压损伤大鼠的运动修复。上述结果表明，每日系统性白藜芦醇治疗可促进神经再生并导致快速运动修复。白藜芦醇在受影响的腹侧脊髓中激活 p300 乙酰转移酶介导的 VEGF 信号传导，从而可能有助于加速神经再生和运动修复。
Peripheral nerve injuries are generally associated with incomplete restoration of motor function. The slow rate of nerve regeneration after injury may account for this. Although many benefits of resveratrol have been shown in the nervous system, it is not clear whether resveratrol could promote fast nerve regeneration and motor repair after peripheral nerve injury. This study showed that the motor deficits caused by sciatic nerve crush injury were alleviated by daily systematic resveratrol treatment within 10 days. Resveratrol increased the number of axons in the distal part of the injured nerve, indicating enhanced nerve regeneration. In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. The above results indicated that daily systematic resveratrol treatment promoted nerve regeneration and led to rapid motor repair. Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair.
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影响因子：
5.3
作者：
Huang, WC;Chen, CC
通讯作者：
Chen, CC
影响因子：
8
作者：
Gray, MJ;Zhang, J;Gallick, GE
通讯作者：
Gallick, GE
影响因子：
4.3
作者：
Johnson, W. D.;Morrissey, R. L.;Usborne, A. L.;Kapetanovic, I.;Crowell, J. A.;Muzzio, M.;McCormick, D. L.
通讯作者：
McCormick, D. L.
影响因子：
--
作者：
Grinsell D;Keating CP
通讯作者：
Keating CP
DOI：
10.1073/pnas.0610068104
发表时间：
2007-04-24
影响因子：
11.1
作者：
Dasgupta, Biplab;Milbrandt, Jeffrey
通讯作者：
Milbrandt, Jeffrey