Asymmetry in RNA pseudoknots: observation and theory.

Asymmetry in RNA pseudoknots: observation and theory.
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DOI:
10.1093/nar/gki508
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发表时间:
2005
影响因子:
14.9
通讯作者:
Hodas NO
Hodas NO
中科院分区:
生物学2区
文献类型:
--
作者:
Aalberts DP;Hodas NO

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RNA可以折叠成称为假结的拓扑结构,由单链环连接的非嵌套双链茎组成。我们的检查的PseudoBase数据库的pseudoknotted RNA结构揭示了不对称的茎和环的长度和挑衅性的组成差异之间的循环。考虑到RNA双螺旋的主要和次要凹槽之间的差异,我们用一个简单的聚合物物理模型和统计力学理论解释了大部分的不对称性,只有一个可调参数。
RNA can fold into a topological structure called a pseudoknot, composed of non-nested double-stranded stems connected by single-stranded loops. Our examination of the PseudoBase database of pseudoknotted RNA structures reveals asymmetries in the stem and loop lengths and provocative composition differences between the loops. By taking into account differences between major and minor grooves of the RNA double helix, we explain much of the asymmetry with a simple polymer physics model and statistical mechanical theory, with only one adjustable parameter.
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